Anti-ageing effects of Sonchus oleraceus L. (pūhā) leaf extracts on H₂O₂-induced cell senescence

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Zong-Quan OuArlene McDowell

Abstract

Antioxidants protect against damage from free radicals and are believed to slow the ageing process. Previously, we have reported the high antioxidant activity of 70% methanolic Sonchus oleraceus L. (Asteraceae) leaf extracts. We hypothesize that S. oleraceus extracts protect cells against H2O2-induced senescence by mediating oxidative stress. Premature senescence of young WI-38 cells was induced by application of H2O2. Cells were treated with S. oleraceus extracts before or after H2O2 stress. The senescence- associated β-galactosidase (SA-β-gal) activity was used to indicate cell senescence. S. oleraceus extracts showed higher cellular antioxidant activity than chlorogenic acid in WI-38 cells. S. oleraceus extracts suppressed H2O2 stress-induced premature senescence in a concentration-dependent manner. At 5 and 20 mg/mL, S. oleraceus extracts showed better or equivalent effects of reducing stress-induced premature senescence than the corresponding ascorbic acid treatments. These findings indicate the potential of S. oleraceus extracts to be formulated as an anti-ageing agent.

References

Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L Packer, J R Smith
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jul 27, 2000·Annals of the New York Academy of Sciences·T von Zglinicki
Mar 23, 2002·Experimental Gerontology·Federica I WolfAchille Cittadini
Jul 1, 1956·Journal of Gerontology·D HARMAN
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Dec 22, 2004·Mechanisms of Ageing and Development·T von ZglinickiS P Jackson
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Kyoung Ah KangJin Won Hyun
Oct 2, 2007·Journal of Agricultural and Food Chemistry·Kelly L Wolfe, Rui Hai Liu
Feb 20, 2008·Mutagenesis·Andrew R CollinsRudolf Stetina
Jun 10, 2008·Biogerontology·F A C WiegantJ A Post
Sep 2, 2008·Journal of Agricultural and Food Chemistry·Kelly L WolfeRui Hai Liu
May 8, 2009·Cellular and Molecular Life Sciences : CMLS·Eun Seong HwangHyun Tae Kang
Sep 25, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Gerard NoppeAndrea B Maier
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Mi Jin ChoiEun Ju Cho
Oct 1, 2007·Nutrition Research and Practice·Jie YinMyeong-Hyeon Wang
Apr 20, 2010·Journal of Dermatological Science·Hitoshi Masaki
May 14, 2010·Journal of Agricultural and Food Chemistry·Wei SongRui Hai Liu
Jul 22, 2010·International Journal of Cosmetic Science·A T S JorgeP L Moreira
Jul 29, 2011·Natural Product Research·Dao-Zong XiaZhuang-Dan Zou
Jun 1, 2012·Archives of Oral Biology·Symone M San MiguelKathy K H Svoboda
Sep 24, 2013·Natural Product Reports·Aikaterini ArgyropoulouAlexios-Leandros Skaltsounis
Nov 19, 2013·Archives of Gerontology and Geriatrics·Yue ZhouBei-Wei Zhu
Apr 5, 2014·The Journal of Pharmacy and Pharmacology·Zong-Quan OuArlene McDowell

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Citations

Sep 15, 2016·Critical Reviews in Food Science and Nutrition·Rúbia C G CorrêaIsabel C F R Ferreira
Sep 13, 2017·Oxidative Medicine and Cellular Longevity·Ana Ortiz-EspínFrancisca Sevilla
Mar 1, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Mahdieh ShirzadMohammad Hossein Modarressi
Jan 3, 2020·Anti-cancer Agents in Medicinal Chemistry·Hongying ZhangBing Liu
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·Liliana Torres-GonzálezPaula Cordero-Pérez
Dec 10, 2019·Journal of Ethnopharmacology·S van Vuuren, L Frank
Dec 17, 2020·Pharmaceutics·Jasper Z S ChiuArlene McDowell

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