Anti-aging effects of anti-lipolytic drugs

Experimental Gerontology
Alessio DonatiEttore Bergamini

Abstract

Genetic disruption of insulin and insulin-like signaling pathways may extend lifespan. Hyperinsulinemia and insulin resistance may accelerate aging. The hypothesis was tested that a once-a-week life-long inhibition of insulin secretion by the administration of anti-lipolytic drugs might have anti-aging effects. Groups of 3-month-old male Sprague-Dawley rats were (a) given standard laboratory food ad libitum (AL); (b) fed AL 6 days and fasted 1 day every week (FW); (c) fed AL every other day (EOD), (d) fed like FW and given Acipimox (50 mg/kg b.w.) on the day of fasting (FWA) by the gastric tube. The AL, FW and EOD groups received saline intragastrically. Treatment with ACIPIMOX transiently decreased plasma free fatty acids, glucose and insulin and increased valine plasma levels, and had no long-term effect on food consumption and body weight. By age 6, 12 and 24 months subgroups were taken and the age-related changes in liver dolichol and autophagic proteolysis--which are correlated with life-expectancy--were measured. Liver dolichol levels increased and autophagic proteolysis decreased in mature and older AL rats; EOD and FWA fully counteracted these changes; FW rats had significant but smaller beneficial effects. It is conclu...Continue Reading

References

Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ward, A Richardson
Nov 12, 1990·Biochimica Et Biophysica Acta·M MarinoA Trentalance
Mar 29, 1985·Biochimica Et Biophysica Acta·T Locci CubedduE Bergamini
Sep 1, 1971·Endocrinology·P S ScheinD H Williamson
Sep 1, 1974·Diabetes·R ParrillaC J Toews
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Jun 1, 1983·Biochemical Pharmacology·T Locci-Cubeddu, E Bergamini
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P O Seglen, P B Gordon
Jul 15, 1981·Analytical Biochemistry·Y TapuhiB L Karger
Dec 2, 1993·Nature·C KenyonR Tabtiang
Aug 1, 1993·Experimental and Molecular Pathology·E BergaminiM Pollera
Aug 1, 1995·Archives of Physiology and Biochemistry·E BergaminiS Vittorini
Feb 15, 1996·European Journal of Biochemistry·I HolenP O Seglen
Jun 15, 1996·The Journal of Clinical Investigation·D T SteinJ D McGarry
Nov 7, 1996·Nature·H M Brown-BorgA Bartke
Apr 1, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M MarinoE Bergamini
Dec 2, 2000·Science·D J Klionsky, S D Emr
May 5, 2001·Cell·C Kenyon
Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·A Bartke
Aug 29, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A DonatiE Bergamini
Dec 12, 2001·Experimental Gerontology·B DiniE Bergamini
Jun 5, 2002·Trends in Genetics : TIG·Christy S CarterWilliam E Sonntag
Jul 3, 2002·Aging Clinical and Experimental Research·Gabriella CavalliniEttore Bergamini
Jan 25, 2003·Experimental Gerontology·Julie A MattisonDonald K Ingram
Jan 25, 2003·Science·Matthias BlüherC Ronald Kahn
Mar 1, 2003·Science·Marc TatarAdam Antebi
May 14, 2003·Experimental Gerontology·Alessandra Del RosoEttore Bergamini
Jul 8, 2003·Science of Aging Knowledge Environment : SAGE KE·Edward J Masoro
Sep 12, 2003·Science of Aging Knowledge Environment : SAGE KE·Ana Maria Cuervo
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Helene NørrelundNiels Møller

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Citations

Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J Christopher Corton, Holly M Brown-Borg
Apr 30, 2008·Human Molecular Genetics·Guillermo MariñoCarlos López-Otín
Aug 16, 2011·Molecular Aspects of Medicine·John R Speakman, Sharon E Mitchell
Feb 16, 2010·Ageing Research Reviews·Hiroshi KogaAna Maria Cuervo
Sep 24, 2015·Nutrition Research Reviews·Sibylle NikolaiGerald Rimbach
Oct 16, 2007·Annals of the New York Academy of Sciences·Ettore BergaminiZina Gori
Apr 22, 2006·Aging Cell·Donald K IngramRafael deCabo
Sep 16, 2006·Molecular Aspects of Medicine·Alessio Donati
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Ettore Bergamini
Dec 18, 2007·Biochemical and Biophysical Research Communications·Alessio DonatiEttore Bergamini
Mar 17, 2007·Lancet Neurology·Marta Martinez-Vicente, Ana Maria Cuervo
May 29, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Jyoti M Benni, Paragouda A Patil
Jul 29, 2017·Oxidative Medicine and Cellular Longevity·Xiaofei ZhuWenjuan Zhu
Sep 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·William D WatsonOliver J Rider
May 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sarbari SahaSujit K Bhutia

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