Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid.

Journal of Natural Products
M NishizawaK H Lee

Abstract

Four new tetragalloylquinic acids, 3,5-di-O-galloyl-4-O-digalloylquinic acid, 3,4-di-O-galloyl-5-O-digalloylquinic acid, 3-O-digalloyl-4,5-di-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid, were isolated and characterized from a commercial tannic acid as a new class of human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitor. Compounds 2, 3, and 4 inhibit HIV RT activity 90, 89, and 84% at 100 microM and 73, 70, and 63% at 30 microM, respectively. Compounds 2-5 also inhibit the HIV growth in cells in the range of 61-70% with low cytotoxicity at 25 microM. The HIV cell growth inhibitory effects of these compounds at 25 microM and 6.25 microM (44-57%) are comparable to their effects against the HIV RT at 30 microM and 10 microM, respectively. The inhibitory effect of 3 against DNA polymerases indicates that the selective antiviral action of 3 is determined by more than its action with HIV RT.

Citations

Jun 9, 1992·Biochemical Pharmacology·J L WeaverA Aszalos
Dec 1, 1990·Antiviral Research·W KreisP S Sarin
Jun 13, 2002·Critical Reviews in Food Science and Nutrition·Amy B Howell
Jun 1, 1992·AIDS Research and Human Retroviruses·R F SchinaziP M Feorino
Sep 2, 2004·Biological & Pharmaceutical Bulletin·Maira Huerta-ReyesRicardo Reyes-Chilpa
Jan 1, 1994·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·B L BuchkoD J Lerew
Dec 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M CouladisH Skaltsa
May 17, 2011·Journal of Pharmaceutical and Biomedical Analysis·Mariateresa MaldiniCosimo Pizza
Jan 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K KondoT Higuti
Aug 5, 2006·Medicinal Research Reviews·Donglei YuKuo-Hsiung Lee
Dec 10, 1999·Journal of Mass Spectrometry : JMS·P MiketovaB N Timmermann
Jul 24, 2020·Future Microbiology·Jhonatan M RibeiroGerson Nakazato
May 1, 1993·Journal of Pharmaceutical Sciences·Y KashiwadaK H Lee
Mar 27, 2007·Journal of Agricultural and Food Chemistry·Michael N CliffordNikolai Kuhnert

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