Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial

Clinical and Experimental Nephrology
Sawako KatoSeiichi Matsuo

Abstract

Several studies have demonstrated that spironolactone has an anti-albuminuric property in diabetic nephropathy. As an adverse event, spironolactone often induces the elevation of creatinine levels with hypotension and hyperkalemia. Therefore, we aimed to evaluate the efficacy and safety of spironolactone in Japanese patients with type 2 diabetes treated with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Fifty-two Japanese patients with diabetic nephropathy and albuminuria (100 mg/gCr-2000 mg/gCr) treated with renin-angiotensin system (RAS) blockade were enrolled in a prospective, randomized, open-label study. The patients were subjected to add-on treatment with spironolactone 25 mg once daily and compared with matched controls for 8 weeks. The primary outcome was a reduction in the rate of albuminuria at 8 weeks compared with the baseline value. This study was registered with UMIN Clinical Trials Registry (000008016). Albuminuria was reduced by 33 % (95 % confidence interval: 22-54; P = 0.0002) at 8 weeks with spironolactone. In the spironolactone group, blood pressure tended to lower and the estimated glomerular filtration rate (eGFR) was significantly decreased compared to those in the cont...Continue Reading

References

Mar 1, 1991·Kidney International·F N Ziyadeh, S Goldfarb
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Sep 22, 2001·The New England Journal of Medicine·A Chrysostomou, G Becker
Jan 4, 2003·Hypertension·Atsuhisa SatoTakao Saruta
Oct 2, 2004·Kidney International·Genro FujisawaShun Ishibashi
May 13, 2005·Journal of the American Society of Nephrology : JASN·Hiroyuki KoboriAkira Nishiyama
Sep 22, 2005·Nephrology·Kunitoshi Iseki
Dec 1, 2005·Kidney International·Katrine Jordan SchjoedtHans-Henrik Parving
Oct 21, 2006·Journal of Hypertension·Anton H van den MeirackerFrans Boomsma
Mar 29, 2007·Diabetes Care·Hirofumi MakinoUNKNOWN INNOVATION Study Group
Dec 1, 2007·American Journal of Hypertension·Takashi YonedaMasakaz Yamagishi
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S BombackPhilip J Klemmer
Sep 9, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R Bilous
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Jan 18, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shigeru NakaiYoshiharu Tsubakihara
Aug 16, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru HorioUNKNOWN Collaborators Developing the Japanese Equation for Estimated GFR
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Enrique MoralesManuel Praga
Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alireza EsteghamatiManouchehr Nakhjavani

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Citations

Feb 18, 2016·Current Diabetes Reports·Collen Majewski, George L Bakris
Jan 21, 2017·Journal of Diabetes Investigation·Li-Jing SunGeng-Ru Jiang
Jan 22, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Abdus Sattar BhuiyanAkira Nishiyama
Feb 9, 2019·International Urology and Nephrology·Dan DongLi Zhang
Mar 9, 2019·Current Pharmaceutical Design·Vasilios G AthyrosAsterios Karagiannis
Mar 9, 2019·Current Pharmaceutical Design·Pantelis A SarafidisAikaterini Papagianni
Dec 15, 2017·Expert Opinion on Drug Discovery·Magdalena KrochmalHarald Mischak
Aug 10, 2017·Current Hypertension Reports·Fan ZhangHongqing Zhang
Jun 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi ItohSatoshi Nishioka
Oct 26, 2016·Current Opinion in Nephrology and Hypertension·Netanya Y Spencer, Robert C Stanton
Jan 7, 2017·Cardiovascular Diabetology·Alon Grossman, Ehud Grossman
Feb 10, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Yanhuan FengPing Fu
Nov 18, 2018·Current Clinical Pharmacology·Luxitaa GoenkaMelvin George
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Yan LiMin Liang
Oct 28, 2020·The Cochrane Database of Systematic Reviews·Edmund Ym ChungGiovanni Fm Strippoli
Nov 13, 2020·Drug Development Research·Vishal PatelMukul Jain
Nov 7, 2020·Mayo Clinic Proceedings·Alex M SecoraMorgan E Grams
Oct 8, 2020·Pharmacology & Therapeutics·Cosimo CosimatoThomas A Mavrakanas
Feb 2, 2021·World Journal of Diabetes·Ning-Ning HouXiao-Dong Sun
Dec 6, 2020·Journal of Cardiovascular Pharmacology·Christopher S Wilcox, Bertram Pitt
May 21, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lorenzo Villa-ZapataDaniel C Malone
May 5, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alberto OrtizUNKNOWN European Renal and Cardiovascular Medicine (EURECA-m) working group of the European Renal Association—European Dialysis and

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