Anti-allergic activity of crystallinity controlled N-acetyl glucosamine

Immunopharmacology and Immunotoxicology
Se-Eun JinHyun-Ja Jeong

Abstract

Chitin is the polysaccharide and is found in insects, parasites and fungi. Chitin has shown various immunological effects in in vivo and in vitro models. In this study, crystallinity controlled N-acetyl glucosamine (CCG) which has a high solubility was prepared from the low molecular weight chitosan. However, the effect of CCG in an allergic response is not clear. To investigate the effect and regulatory mechanism of CCG on allergic responses. To demonstrate the effect of CCG, we induced systemic anaphylactic shock, ear swelling response, passive cutaneous anaphylaxis (PCA), and inflammatory reaction. CCG inhibited the compound 48/80-induced systemic anaphylactic shock and ear swelling responses. IgE-mediated PCA was inhibited by the oral administration or topical application of CCG. Histamine and β-hexosaminidase release from mast cells was decreased with the treatment of CCG. CCG also inhibited phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced interleukin-1β production and mRNA expression by suppressing NF-κB activation and IκBα phosphorylation. Furthermore, CCG suppressed the activation of caspase-1. These results suggest that CCG may have beneficial applicability as a candidate for an anti-allergic agent.

References

Jan 1, 1994·Annual Review of Microbiology·M Debono, R S Gordee
Apr 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A C AraujoW de Souza
Jan 1, 1997·Annual Review of Immunology·M Daëron
Dec 9, 1997·Cell·G S Salvesen, V M Dixit
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y ShibataQ N Myrvik
Dec 5, 2000·Current Opinion in Immunology·J WedemeyerS J Galli
Jan 22, 2005·Nature Immunology·Stephen J GalliMindy Tsai
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Jack A EliasChun Geun Lee
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H-J JeongS-H Hong
Jul 25, 2008·Nature·Stephen J GalliAdrian M Piliponsky
Mar 7, 2009·Cellular and Molecular Life Sciences : CMLS·H J JeongS H Hong
Apr 9, 2010·Journal of Innate Immunity·Amir S YazdiStefan K Drexler
Jul 14, 2010·International Immunopharmacology·Hui-Di QinZhao-Ping Liu
Oct 16, 2010·Immunopharmacology and Immunotoxicology·Na-Hyung KimHyun-Ja Jeong
Nov 13, 2010·Cellular and Molecular Life Sciences : CMLS·Franz BauernfeindVeit Hornung
Dec 2, 2010·Cell Research·Jens StaalRudi Beyaert
Jan 18, 2011·International Immunopharmacology·Na-Ra HanHyun-Ja Jeong

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Citations

Nov 28, 2017·Allergy, Asthma & Immunology Research·Young Hyo KimJayakar Nayak
Oct 18, 2013·Experimental Biology and Medicine·Hyun-A OhHyun-Ja Jeong
May 31, 2017·International Forum of Allergy & Rhinology·Ah-Yeoun JungYoung Hyo Kim
Mar 7, 2021·Nutrients·Nathalie AcevedoBetty C A M van Esch
Oct 1, 2019·Annals of Dermatology·Hee Seong YoonGwang Seong Choi

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