Anti-Allergic Effect of Ulmus davidiana Cortex on Contact Dermatitis Induced by Dinitrofluoro- Benzene in Mice

Journal of Pharmacopuncture
Jeonghyeon LyuHyungwoo Kim

Abstract

The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. In the present study, we used 1-fluoro-2,4- dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production. URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation, topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum. These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.

References

Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·J Machado-PintoL E Golitz
Aug 11, 2001·The Journal of Allergy and Clinical Immunology·D H Broide
Aug 26, 2004·Dermatologic Therapy·David E Cohen, Noushin Heidary
Sep 15, 2005·The Journal of Allergy and Clinical Immunology·Ming-Chun WenXiu-Min Li
Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Shuishi JiangChiaki Kamei
Jun 18, 2010·Journal of Medicinal Food·Sang Yoon ChoiTae-Youl Ha
Jan 1, 2007·Environmental Toxicology and Pharmacology·In-Kwang SongCheorl-Ho Kim
Jul 26, 2012·Recent Patents on Inflammation & Allergy Drug Discovery·Adewonuola Alase, Miriam Wittmann

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SYSTAT
SigmaPlot

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