Anti-allergic inflammatory activity of the fruit of Prunus persica: role of calcium and NF-kappaB

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Tae-Yong ShinS H Kim

Abstract

Mast cell-mediated allergic symptoms are involved in many diseases, such as asthma and sinusitis. In this study, we investigated the effect of ethanol extract of fruits of Prunus persica (L) Batsch (FPP) on the mast cell-mediated allergic inflammation and studied the possible mechanism of action. FPP dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. Histamine releasing from mast cells was reduced by FPP, which was mediated by modulation of intracellular calcium. In addition, FPP attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of FPP on pro-inflammatory cytokines was nuclear factor (NF)-kappaB dependent. Our findings provide evidence that FPP inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-kappaB in these effects.

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Citations

Jan 11, 2012·Bioscience, Biotechnology, and Biochemistry·Miyuki ShirosakiKazunaga Yazawa
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Pablo C StampellaMaría Lelia Pochettino

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