Anti-allergic inflammatory components from Sanguisorba officinalis L

Bioorganic & Medicinal Chemistry Letters
Xiang Dong SuSeo Young Yang

Abstract

Sanguisorba officinalis L. was well known as a traditional herbal medicine to treat inflammation and allergic skin diseases. The aim of this research was to indentify compounds with anti-allergic inflammatory property. Twenty-five compounds (1-25) were isolated from S. officinalis including two new compounds (1 and 8), and their chemical structures were identified by NMR and ESIMS analysis. Consequently, the anti-allergic inflammatory activities of these isolates were investigated by inhibiting β-hexosaminidase and IL-4 production in PMA/A23187-stimulated RBL-2H3 cells. Compounds 6, 8, 13, 17-18 and 25 significantly inhibited β-hexosaminidase release and IL-4 production. Additionally, compounds 8, 17 and 25 effectively suppressed the activation of NF-κB and NF-κB p65 translocation into the nucleus. Anti-inflammatory effects of isolated compounds were evaluated in LPS-stimulated RAW264.7 macrophages, and they showed dramatic inhibition on LPS-induced overproduction of nitric oxide (NO) and TNF-α. Consistently, the protein levels of iNOS and COX-2 were remarkably decreased by the single compounds 8, 13 and 25. These results showed that compounds 8, 13 and 25 from S. officinalis may have a therapeutic potential for allergic inflam...Continue Reading

Citations

Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan
Aug 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Da-Le GuoYun Deng
Oct 22, 2020·Revista brasileira de enfermagem·Fabiana Verdan SimõesRafael Celestino da Silva
Nov 3, 2020·Biological & Pharmaceutical Bulletin·Hitomi KawakamiNobuo Kawahara
Dec 4, 2020·Journal of the Science of Food and Agriculture·Yang ZhangZhaowei Yan
Feb 2, 2021·Biological & Pharmaceutical Bulletin·Yue GongYoung Ran Kim
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weijia ZhangMeicun Yao
Apr 2, 2019·Journal of Natural Products·Xiang-Dong SuSeo Young Yang

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