Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jaime Ribeiro-FilhoPatrícia T Bozza

Abstract

Curine is a bisbenzylisoquinoline alkaloid isolated from Chondrodendron platyphyllum (Menispermaceae). Recent findings have shed light on the actions of curine in different models of allergy and inflammation. Here we review the properties and mechanisms of action of curine focusing on its anti-allergic effects. Curine pre-treatment significantly inhibited the scratching behavior, paw edema and systemic anaphylaxis induced by either ovalbumin (OVA) in sensitized animals or compound 48/80, through mechanisms of mast cell stabilization and inhibition of mast cell activation to generate lipid mediators. In addition, oral administration of curine significantly inhibited eosinophil recruitment and activation, as well as, OVA-induced airway hyper-responsiveness in a mouse model of asthma, through inhibition of the production of IL-13 and eotaxin, and of Ca2+ influx. In conclusion, curine exhibit anti-allergic effects in models of lung, skin and systemic allergy in the absence of significant toxicity, and as such has the potential for anti-allergic drug development.

References

Oct 1, 1992·Pain·A TjølsenK Hole
Jan 1, 1990·International Journal of Immunopharmacology·B S TehY H Thong
Mar 1, 1984·British Journal of Pharmacology·R W FosterR C Small
Jan 1, 1993·Annual Review of Medicine·G J GleichK M Leiferman
Jan 1, 1996·Scandinavian Journal of Rheumatology. Supplement·J R Vane, R M Botting
Feb 1, 1997·British Journal of Pharmacology·A S Ash, H O Schild
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
Jun 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards, J B Howell
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M HuberG Krystal
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M LloydJ C Gutierrez-Ramos
Sep 5, 2002·The Journal of Allergy and Clinical Immunology·Stephen F Kemp, Richard F Lockey
Nov 27, 2002·Planta medica·Celidarque S DiasSteyner F Côrtes
Aug 5, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Joshua A Boyce
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pascale ChomaratA Karolina Palucka
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·E B CookF M Graziano
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Niti PuriPaul A Roche
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Adriana Vieira-de-AbreuPatrícia T Bozza
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Douglas A KupermanDavid J Erle
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Maria Alejandra HossenChiaki Kamei
Feb 14, 2006·Nature Reviews. Immunology·Alasdair M Gilfillan, Christine Tkaczyk
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
May 23, 2006·International Immunopharmacology·Cláudio R Bezerra-SantosPatrícia T Bozza
Sep 16, 2006·Journal of Leukocyte Biology·Rajwardhan YadavAnthony T Vella
Sep 19, 2006·Biochemical and Biophysical Research Communications·Kazuhiko TatemotoTakayuki Naito
Jul 7, 2007·Sub-cellular Biochemistry·K D Rainsford
Aug 11, 2007·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson
Sep 4, 2007·Immunology Letters·Karolien BloemenGreet Schoeters
Feb 16, 2008·Nature Reviews. Immunology·Stephen T Holgate, Riccardo Polosa
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
Feb 28, 2008·Nature Reviews. Immunology·Hannah J Gould, Brian J Sutton
Sep 3, 2008·Cellular & Molecular Immunology·Mamoru Nakanishi, Tadahide Furuno
Oct 1, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Marcos Antônio A MedeirosJader S Cruz
Apr 7, 2009·Cell Calcium·Damian B van Rossum, Randen L Patterson
Sep 23, 2009·Mutation Research·Jenna R Murdoch, Clare M Lloyd
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Feb 25, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Monique A M Willart, Hamida Hammad
Mar 26, 2010·Nature Reviews. Immunology·William E Paul, Jinfang Zhu
Apr 14, 2010·Allergy·J Buddenkotte, M Steinhoff

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Citations

Aug 24, 2019·Critical Reviews in Food Science and Nutrition·Kexin WangZhenxing Li
Dec 9, 2020·International Journal of Molecular Sciences·Jaime Ribeiro-FilhoMárcia Regina Piuvezam

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