Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis

Clinical Reviews in Allergy & Immunology
Yves RenaudineauPierre Youinou

Abstract

Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-alpha-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Guéguen et al., J Clin Immunol 26:495-505, 2006). As anti-alpha-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-alpha-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-alpha-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against alpha-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients.

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Citations

Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Yaniv ShererYehuda Shoenfeld
Jan 15, 2008·Clinical Reviews in Allergy & Immunology·Pierre Youinou
Aug 1, 2013·World Journal of Gastroenterology : WJG·Priscila Menezes Ferri LiuAna Cristina Simões e Silva
Jul 16, 2011·Hepatitis Research and Treatment·Ashima MakolVaidehi R Chowdhary
May 14, 2010·Digestive Diseases and Sciences·Albert J Czaja
Dec 22, 2011·Digestive Diseases and Sciences·Albert J Czaja
Nov 5, 2011·Alimentary Pharmacology & Therapeutics·K ZachouG N Dalekos
Aug 13, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Kalliopi ZachouGeorge N Dalekos
Jun 28, 2016·Clinical Reviews in Allergy & Immunology·Laurent SimoninYves Renaudineau
Dec 15, 2012·Expert Review of Gastroenterology & Hepatology·Maria I S AchenzaCarlo Selmi
Sep 10, 2013·Alimentary Pharmacology & Therapeutics·K ZachouL Muratori
Dec 22, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cara L MackAlbert J Czaja
Aug 4, 2010·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Aug 1, 2013·Auto- Immunity Highlights·Takashi Himoto, Mikio Nishioka
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bénédicte CauweGhislain Opdenakker
Jan 13, 2015·World Journal of Gastroenterology : WJG·Nikolaos K GatselisGeorge N Dalekos
Jul 21, 2021·Wiener klinische Wochenschrift·Mohammed A KhedrMostafa M Sira
May 11, 2010·Gastroenterology·Albert J Czaja, Michael P Manns
Jan 19, 2011·Autoimmunity Reviews·Katerina G OikonomouGeorge N Dalekos

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