Anti-alpha-enolase antibody as a serologic marker and its correlation with disease severity in intestinal Behçet's disease.

Digestive Diseases and Sciences
Sung Jae ShinWon Ho Kim

Abstract

Intestinal Behçet's disease (BD) is a chronic inflammatory bowel disease, as are Crohn's disease (CD) and ulcerative colitis (UC). But unlike CD and UC, serologic markers for intestinal BD are not well known. Recently, anti-α-enolase antibody (AAEA) has been detected in sera from BD patients. The aim of this study was to evaluate the prevalence of AAEA in intestinal BD and its clinical correlations. The study sample included 80 patients with intestinal BD and 23 healthy controls. IgM AAEA was detected by ELISA. The positivity of IgM AAEA was defined as an optical density greater than three standard deviations above the mean of the control sera. Other parameters, such as demographic information, subtype of BD, colonoscopic findings, disease severity and treatment modality, were analyzed retrospectively. The prevalence of IgM AAEA was 67.5% in intestinal BD and 0% in the control group. The positivity rate of IgM AAEA was higher in complete or incomplete BD than in suspected BD (77.5% vs. 51.6%, P = 0.016). The mean HBI score was higher in antibody positive patients than in antibody negative patients (5.60 vs. 4.61, P = 0.003). The cumulative probability of steroid use for aggravation of intestinal and extra-intestinal symptoms wa...Continue Reading

References

Apr 1, 1991·Archives of Disease in Childhood·F A Riordan, D C Davidson
Aug 1, 1990·The Journal of Allergy and Clinical Immunology·A SaxonS Targan
May 1, 1993·Clinical Immunology and Immunopathology·A O AydìntugG R Hughes
Mar 1, 1996·Clinical and Diagnostic Laboratory Immunology·B SendidD Poulain
Mar 26, 1998·Seminars in Arthritis and Rheumatism·V G KaklamaniP G Kaklamanis
May 5, 1998·Clinical and Experimental Immunology·C RoozendaalC G Kallenberg
Jun 11, 1998·The Journal of Biological Chemistry·V Pancholi, V A Fischetti
Sep 30, 1998·Gastroenterology·F M RuemmeleE G Seidman
Oct 21, 1999·The New England Journal of Medicine·T SakaneG Inaba
Apr 6, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·V M GitlitsJ W Sentry
Jul 14, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S Y ChungY I Min
Aug 11, 2001·Cellular and Molecular Life Sciences : CMLS·V Pancholi
Aug 23, 2001·Inflammatory Bowel Diseases·C R LeeD Bang
Dec 16, 2003·Current Opinion in Rheumatology·Sebahattin YurdakulHasan Yazici

❮ Previous
Next ❯

Citations

Jan 31, 2013·International Reviews of Immunology·Robert B NussenblattH Nida Sen
Jan 1, 2011·Japanese Clinical Medicine·Yui HiuraShinichi Moriwaki
Jul 4, 2017·Intestinal research·Hyun Jung Lee, Jae Hee Cheon
Aug 7, 2013·Yonsei Medical Journal·Jae Jun ParkJae Hee Cheon
Feb 4, 2014·The Journal of Rheumatology·Gulen HatemiHasan Yazici
Apr 22, 2017·Pediatric Rheumatology Online Journal·Simona ValentiClaudio Romano
Apr 9, 2015·World Journal of Gastroenterology : WJG·Wasseem SkefThurayya Arayssi
Aug 16, 2019·Rheumatology International·Asli Kirectepe AydinEda Tahir Turanli
Dec 15, 2020·Journal of Digestive Diseases·Liang GongDong Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.