Anti-amnesic effect of Ficus religiosa in scopolamine-induced anterograde and retrograde amnesia

Pharmaceutical Biology
Harjeet KaurRajesh Kumar Goel

Abstract

Ficus religiosa Linn (Moraceae) is a variety of fig tree. Its figs are known to contain a high serotonergic content, and modulation of serotonergic neurotransmission plays a crucial role in the pathogenesis of amnesia. Thus, the present study was envisaged. To investigate the effect of the methanol extract of figs of Ficus religiosa (FRFE) on scopolamine-induced anterograde and retrograde amnesia in mice. Transfer latency (TL) to the preferred niche in the elevated plus-maze (EPM) and learning avoidance of passive behavior to avoid punishment in the modified passive avoidance paradigm (MPA) served as behavioral models for the assessment of memory. Scopolamine (1 mg/kg, i.p.) was administered before training for induction of anterograde amnesia and before retrieval for induction of retrograde amnesia in both models. TL in the EPM, step down latency (SDL), number of trials, and number of mistakes in the MPA were determined in vehicle control, FRFE treated (10, 50, and 100 mg/kg, i.p.), and standard groups (piracetam 200 mg/kg, i.p.). Cyproheptadine, a non-selective 5-HT(1/2) blocker (4 mg/kg, i.p.), was administered along with the FRFE to investigate the involvement of serotonergic pathways in the anti-amnesic effect of FRFE. FRF...Continue Reading

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Citations

Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ben A ChindoAxel Becker
Feb 8, 2011·Journal of Ethnopharmacology·Damanpreet SinghRajesh Kumar Goel
May 11, 2011·European Journal of Pharmacology·Navneet KhuranaRajesh Kumar Goel
Nov 29, 2011·European Journal of Pharmacology·Awanish Mishra, Rajesh Kumar Goel
Nov 5, 2016·BMC Complementary and Alternative Medicine·Dipesh Raj Panday, G P Rauniar
Sep 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Noor Azuin SulimanRusliza Basir
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Camila CalfioRicardo B Maccioni
Apr 5, 2012·Pharmaceutical Biology·Damanpreet SinghRajesh Kumar Goel
May 30, 2017·Neural Regeneration Research·Muhammad Akram, Allah Nawaz
Oct 8, 2020·Phytotherapy Research : PTR·Bahare SalehiJavad Sharifi-Rad
May 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Babita AryalNiranjan Parajuli

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