Anti-angiogenesis agent DS-4152 is a potent and selective inhibitor of HIV-1 replication in vitro

AIDS
M BabaY Osada

Abstract

To determine whether the anti-angiogenesis agent DS-4152 inhibits the replication of HIV-1 in vitro. A sulfated polysaccharide-peptidoglycan DS-4152 has recently been identified as a potent and selective inhibitor of Kaposi's sarcoma (KS). Therefore, it is important to evaluate the anti-HIV-1 activity of DS-4152 alone and in combination with dideoxynucleosides. Activity of DS-4152 against HIV-1 replication was examined in MT-4, Molt-4, and peripheral blood lymphocyte cells. The inhibitory effect of the compound on syncytium-formation was determined by cocultivation of Molt-4 cells with Molt-4/IIIB cells. Inhibition of virus adsorption to the host cells was measured by a p24 antigen capture enzyme-linked immunosorbent assay. DS-4152 showed potent and selective inhibition of HIV-1 replication in the cell systems. Its 50% effective concentration for HIV-1 (IIIB strain) in MT-4 cells was 0.7 microgram/ml. The compound was not cytotoxic at concentrations < or = 100 micrograms/ml. DS-4125 proved inhibitory to syncytium-formation and virus adsorption. The anti-HIV-1 activities of zidovudine, dideoxycytidine and dideoxyinosine were not affected by the presence of DS-4152. DS-4152 has the potential, from these in vitro studies, to funct...Continue Reading

Citations

Jul 5, 2005·Expert Opinion on Investigational Drugs·H T Zhang, A L Harris
Apr 10, 2016·International Journal of Biological Macromolecules·Anthony J SaviolaStephen P Mackessy

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