Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors

Bioorganic & Medicinal Chemistry Letters
Hiroko SanoHiroyuki Miyachi

Abstract

Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).

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Apr 6, 2005·Bioorganic & Medicinal Chemistry·Hiroko SanoHiroyuki Miyachi

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Citations

Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Jan 5, 2007·Chemical & Pharmaceutical Bulletin·Norbert HandlerThomas Erker
Mar 5, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ryosuke FukaiHiroki Kakuta
Nov 10, 2009·Brain Research Bulletin·Susan E YanniJohn S Penn
Dec 8, 2009·Medicinal Research Reviews·Mohammed Naseer A Khan, Yong Sup Lee
May 6, 2015·European Journal of Medicinal Chemistry·Marcos Veríssimo de Oliveira CardosoAna Cristina Lima Leite
Jan 30, 2010·ChemMedChem·Claudia PessoaValdênia M O Souza
May 16, 2007·The Journal of Pharmacology and Experimental Therapeutics·Hao SunGarold S Yost
Nov 15, 2016·Molecular Medicine Reports·Fang CaiDuo Li
Jun 20, 2014·Archiv der Pharmazie·Magdy A H ZahranErik B Pedersen
Feb 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Monisha MohanRoy Anindya

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