Anti-angiogenic activity of triterpene acids

Cancer Letters
K H SohnK W Kim

Abstract

Ursolic acid (UA) and oleanolic acid (OA) were examined for anti-angiogenic activities by using the chick embryo chorioallantoic membrane (CAM) assay. The presence of UA or OA inhibited angiogenesis in a dose-dependent manner; the doses required for half-maximal inhibition (ID50) were 5 micrograms and 40 micrograms per CAM, respectively. UA was a more potent angiogenic inhibitor than OA. We also tested for inhibitory effect on the proliferation of bovine aortic endothelial cell. They effectively inhibited the proliferation of bovine aortic endothelial cell in a concentration-dependent manner. The IC50 values of anti-proliferative effects were determined to be 5 microM for UA and 20 microM for OA. Based on these results, we speculated that the inhibitory effects on bovine aortic endothelial cell proliferation of UA and OA might be important for anti-angiogenesis.

References

May 1, 1992·The Journal of Pharmacy and Pharmacology·G B SinghS K Banerjee
Mar 20, 1990·European Journal of Pharmacology·T OikawaA Hiragun
Dec 31, 1991·Biochemical and Biophysical Research Communications·T OikawaI Morita
May 15, 1987·Science·F C KullP Cuatrecasas
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Nov 30, 1989·Cancer Letters·T OikawaT Iwaguchi
Mar 1, 1981·Archives of Biochemistry and Biophysics·R G MeeksR F Chen
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·H Y LeeK W Kim

❮ Previous
Next ❯

Citations

Oct 12, 2001·Biochemical and Biophysical Research Communications·C Y ChoiH G Jeong
Jun 3, 2000·Archives of Pharmacal Research·B S MinK Bae
Mar 21, 2013·Journal of Physiology and Biochemistry·Imran KazmiFiroz Anwar
Jun 1, 2005·Cancer Letters·Eun-Kyoung YimJong-Sup Park
Feb 2, 2012·Natural Product Research·Hooi-Kheng BehZhari Ismail
May 4, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Iris ZellerDavid Bernhard
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·R C SantosJ A Paixão
Dec 21, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E-K YimJ-S Park
Jan 21, 2015·Seminars in Cancer Biology·Zongwei WangLasse D Jensen
Jun 18, 2010·Journal of Ethnopharmacology·Yeon Sil LeeJin-Kyung Kim
Mar 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuanke LiJing Yao
Oct 22, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ming-Huan ShyuGow-Chin Yen
May 2, 2008·Biochemical and Biophysical Research Communications·M S KiranP R Sudhakaran
Jun 6, 2013·International Journal of Cancer. Journal International Du Cancer·Shuilong LengHsiang-fu Kung
Nov 4, 2015·Journal of Asian Natural Products Research·Yan-Qiu MengMin-Jie Zhao
Jul 13, 2006·Mutation Research·Zdenka OvesnáDarina Slamenová
Aug 26, 2014·European Journal of Pharmacology·Arjunan SundaresanKodukkur Viswanathan Pugalendi
Dec 21, 2010·Journal of Ethnopharmacology·Lay-Jing SeowMohd Zaini Asmawi
Mar 9, 2005·The Journal of Medical Investigation : JMI·Piyawan BunpoYoshinari Ohnishi
Dec 19, 2012·Biochimica Et Biophysica Acta·Seoung Woo Shin, Jeen-Woo Park
Oct 27, 2015·Biochemical and Biophysical Research Communications·Masakazu IshiiMasahiro Nishimura
Jun 29, 2004·Biochemical and Biophysical Research Communications·Casimiro CárdenasMiguel Angel Medina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.