Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells

Pharmacological Reports : PR
Alina SesarmanAlina Porfire

Abstract

Emerging treatment options for colon cancer are needed to overcome the limitations regarding the side effects of current chemotherapeutics and drug resistance. The goal of this study was to assess the antitumor actions of PEGylated long-circulating liposomes (LCL) co-delivering curcumin (CURC) and doxorubicin (DOX) on murine colon carcinoma cells (C26). The cytotoxicity of CURC and DOX, administered alone or in combination, either in free or LCL form, was evaluated with regard to antiproliferative effects on C26 cells and to protumor processes that might be affected. Our results indicated that PEGylated LCL-CURC-DOX exerted strong antiproliferative effects on C26 cells, slightly exceeding those induced by free CURC-DOX, but higher than either agent administered alone in their free form. These effects of LCL-CURC-DOX were due to the inhibition of the production of angiogenic/inflammatory proteins in a NF-κB-dependent manner, but were independent of ROS production or AP-1 c-Jun activation. Notable, the anti-angiogenic actions of LCL-CURC-DOX appeared to be much stronger than those induced by the co-administration of CURC and DOX in their free form, on C26 colon cancer cells. LCL-CURC-DOX demonstrated enhanced cytotoxicity on C26 ...Continue Reading

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Citations

Jan 18, 2020·Current Cancer Drug Targets·Kuldeep Rajpoot
Dec 31, 2019·Pharmaceutical Frontiers·Max KullbergHolly A Martinson
May 20, 2020·Frontiers in Pharmacology·Adhimoolam KarthikeyanTaesun Min
Feb 21, 2019·Journal of Microencapsulation·Thi Thanh Thuy TranThi Tho Lam
Apr 27, 2019·Frontiers in Pharmacology·Valentin-Florian RaucaAnca Toiu
Mar 21, 2019·Frontiers in Pharmacology·Kar En WongLay-Hong Chuah
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Jun 27, 2021·Phytotherapy Research : PTR·Korosh MorshediHamed Mirzaei

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