Anti-angiogenic and cytotoxicity studies of some medicinal plants

Planta medica
Kwok-Wen NgKit-Lam Chan

Abstract

Angiogenesis plays an important role in tumor formation and proliferation. The development of anti-angiogenic agents to block new blood vessel growth will inhibit metastasis and induce apoptosis of the cancer cells. Nine medicinal plants, Strobilanthes crispus, Phyllanthus niruri, Phyllanthus pulcher, Phyllanthus urinaria, Ailanthus malabarica, Irvingia malayana, Smilax myosotiflora, Tinospora crispa and blumea balsamifera were screened for anti-angiogenic properties using the rat aortic ring assay. Of these, the methanol extracts of Phyllanthus species and Irvingia malayana exhibited the highest activity. At 100 microg/mL, P. pulcher, P. niruri, P. urinaria and I. malayana recorded an inhibition of 78.8 %, 59.5 %, 56.7 % and 46.4 %, respectively, against rat aortic vascular growth. Their activities were further investigated by the tube formation assay involving human umbilical vein endothelial cells (HUVEC) on Matrigel. I. malayana, P. niruri and P. urinaria showed a significant decrease of 45.5, 37.9 and 35.6 %, respectively, whilst P. pulcher showed a much lower decrease of 15.5 % when compared with that of the rat aortic ring assay. All the plant extracts were evaluated for cytotoxicity on a panel of human cancer cell lines...Continue Reading

Citations

Jul 6, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuxin PangLei Yuan
Mar 31, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Saswati MahapatraKrishna Vanaja Donkena
Oct 26, 2016·BioMed Research International·Zhi-Zhong ZhengYan-Lin Ming
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Runlan LuoZeyao Tang
Oct 18, 2018·Frontiers in Pharmacology·Madamanchi Geethangili, Shih-Torng Ding
May 29, 2019·Natural Product Research·Sio-Hong LamTian-Shung Wu

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