Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Ponesakki GanesanTakashi Hirata

Abstract

Since anti-angiogenic therapy has becoming a promising approach in the prevention of cancer and related diseases, the present study was aimed to examine the anti-angiogenic effect of siphonaxanthin from green alga (Codium fragile) in cell culture model systems and ex vivo approaches using human umbilical vein endothelial cells (HUVECs) and rat aortic ring, respectively. Siphonaxanthin significantly suppressed HUVEC proliferation (p<0.05) at the concentration of 2.5 μM (50% as compared with control) and above, while the effect on chemotaxis was not significant. Siphonaxanthin exhibited strong inhibitory effect on HUVEC tube formation. It suppressed the formation of tube length by 44% at the concentration of 10 μM, while no tube formation was observed at 25 μM, suggesting that it could be due to the suppression of angiogenic mediators. The ex vivo angiogenesis assay exhibited reduced microvessel outgrowth in a dose dependent manner and the reduction was significant at more than 2.5 μM. Our results imply a new insight on the novel function of siphonaxanthin in preventing angiogenesis related diseases.

References

Dec 1, 1988·Acta Pathologica Japonica·M MoriM Awai
Nov 1, 1989·Acta Pathologica Japonica·S KawasakiM Awai
Jan 20, 1999·Current Topics in Microbiology and Immunology·N Ferrara
Feb 1, 2000·Biochemical and Biophysical Research Communications·E A KrugerW D Figg
Mar 31, 2000·Nature Medicine·P Carmeliet
Aug 6, 2000·Circulation Research·D J MantellA E Canfield
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Dec 12, 2001·The Journal of Nutrition·E Kotake-NaraA Nagao
Mar 17, 2004·Molecular Cell·Amir AbdollahiPeter E Huber
Mar 9, 2005·International Journal of Molecular Medicine·Kiminori MatsubaraTakashi Hirata
Mar 16, 2005·Cancer Cell·Ronit Satchi-FainaroJudah Folkman
Jul 23, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Renu VirmaniJagat Narula
Aug 4, 2005·Journal of Agricultural and Food Chemistry·Kiminori MatsubaraMasaharu Mori
Dec 6, 2005·Biochemical and Biophysical Research Communications·Yoshiyuki MizushinaHiromi Yoshida
Dec 13, 2005·Experimental Cell Research·Masabumi Shibuya, Lena Claesson-Welsh
Dec 16, 2005·Nature·Peter Carmeliet
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Dec 21, 2006·Journal of Agricultural and Food Chemistry·Tatsuya SugawaraTakashi Hirata
Feb 17, 2007·Expert Opinion on Investigational Drugs·Edwina N ScottAnne L Thomas
Mar 31, 2007·Nature Reviews. Drug Discovery·Judah Folkman
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emer O Hanrahan, John V Heymach
Apr 29, 2008·The Journal of Biological Chemistry·Seiji MoriYoshikazu Takada
Jul 5, 2008·Biochemical Pharmacology·Akira ShibataTeruo Miyazawa
Oct 28, 2008·Archives of Biochemistry and Biophysics·Tatsuya SugawaraTakashi Hirata
Nov 4, 2008·Life Sciences·Xiang-Yang ZhuLilach O Lerman

❮ Previous
Next ❯

Citations

Oct 1, 2013·BioMed Research International·Farideh NamvarHeshu Sulaiman Rahman
Jun 21, 2014·Marine Drugs·Tatsuya SugawaraTakashi Hirata
Mar 27, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamtinga Richard SawadogoMarc Diederich
Apr 19, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Fang LiuXiangyang Zou
Dec 20, 2011·Biochemical Pharmacology·Alexis LavaudRamaroson Andriantsitohaina
Jan 24, 2015·Annales pharmaceutiques françaises·M El WahidiT Bamhaoud
Jan 14, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zaichang YangDandan Song
Mar 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lenka VarinskaPeter Kruzliak
Nov 2, 2015·Environmental Science and Pollution Research International·Patrick Y K YueEddy Y Zeng
Nov 11, 2017·Critical Reviews in Biotechnology·Panchanathan ManivasaganJunghwan Oh
Jun 14, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Inmaculada LlamasVictoria Béjar
Mar 12, 2019·Mini Reviews in Medicinal Chemistry·Tânia P AlmeidaEduardo Rocha
Feb 23, 2020·Marine Drugs·Noémie CoulombierNicolas Lebouvier
Nov 2, 2018·Journal of Nutritional Science and Vitaminology·Zhuo-Si LiTatsuya Sugawara
Jan 21, 2021·Marine Drugs·Clementina SansoneChristophe Brunet
Mar 23, 2021·Frontiers in Pharmacology·Umme Tamanna Ferdous, Zetty Norhana Balia Yusof
May 11, 2021·Critical Reviews in Food Science and Nutrition·Kristin KruegerMarietta Zille
Jun 1, 2018·Journal of Agricultural and Food Chemistry·Parise AdadiElena Fedorovna Krivoshapkina
Nov 14, 2021·Environmental Science and Pollution Research International·Ichrak JoulakSamia Azabou
Nov 17, 2021·Journal of Biochemical and Molecular Toxicology·Jhansi Nathan, Arunkumar Ramachandran

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.