Anti-angiogenic therapy (bevacizumab) in the management of oral lichen planus

European Journal of Oral Sciences
Maha M Mahmoud, Marwa M Afifi

Abstract

Oral lichen planus (OLP), a mucocutaneous chronic inflammatory disease, is conventionally managed using topical corticosteroid therapy. Given the fact that OLP is strongly linked to angiogenesis, anti-angiogenic drugs, such as bevacizumab, might be introduced as an alternative treatment for contraindicated, non-responsive patients. The aim of the present study was to report the short-term effectiveness and safety of intralesional bevacizumab injection in the management of atrophic/erosive OLP. A case series study was conducted in patients with atrophic/erosive OLP in the buccal mucosa, assigned to receive either 2.5 mg of bevacizumab, by intralesional injection (n = 20, test), or topical 0.1% triamcinolone acetonide ointment (n = 20, control). The size, score, and pain intensity of the lesions were assessed pre- and post-treatment. Tissue biopsies were collected for histopathologic, immunohistochemical, and ultrastructural examination. After 1 wk, the test group had significant reductions both in lesion seize and in pain scores compared with controls. A marked decrease in vascular endothelial growth factor (VEGF) and interleukin-8 immunoexpression was noted in tissue biopsies from bevacizumab-treated lesions compared with contr...Continue Reading

References

Aug 1, 1976·Rheumatology and Rehabilitation·E C HuskissonP J Scott
Nov 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K ThongprasomW Taweesap
Mar 23, 2004·Current Drug Targets. Inflammation and Allergy·Claudia MonacoEwa Paleolog
Jul 15, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A Sklavounou-AndrikopoulouA Karameris
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
Jul 18, 2006·Current Medicinal Chemistry·Girolamo RanieriDomenico Ribatti
Feb 20, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Xiaoan TaoBin Cheng
Mar 7, 2007·Journal of Clinical Immunology·Jozélio Freire CarvalhoYehuda Shoenfeld
Apr 26, 2007·Angiogenesis·Carla CostaRaquel Soares
May 15, 2007·Mediators of Inflammation·Nelson L RhodusFrank Ondrey
Aug 28, 2007·Cornea·Efdal YoeruekPeter Szurman
Jan 31, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xu'e ChenQing Yue
Aug 15, 2009·Medicina oral, patología oral y cirugía bucal·Giuseppe-Alessandro ScardinaEmiliano Maresi
Nov 26, 2010·Otolaryngologic Clinics of North America·Pallavi Parashar
Apr 30, 2011·The New England Journal of Medicine·UNKNOWN CATT Research GroupGlenn J Jaffe
Oct 4, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Giuseppe Alessandro ScardinaPietro Messina
Oct 7, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G V Koukourakis, A Sotiropoulou-Lontou
Oct 12, 2011·Anais Brasileiros De Dermatologia·Marcello Menta Simonsen NicoSilvia Vanessa Lourenço
Mar 23, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Nitasha MittalSangeeta Palaskar
Mar 19, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chang-Sue YangWen-Ming Hsu
Jun 27, 2013·Journal of Oral and Maxillofacial Pathology : JOMFP·Mayura Paul, Devi Charan Shetty
Oct 15, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chuanxia LiuHongmei Zhou
Jun 5, 2014·Frontiers in Bioscience (Elite Edition)·Dario Di StasioAlberta Lucchese

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Citations

Jun 27, 2018·Antioxidants & Redox Signaling·Susheel Kumar NethiChitta Ranjan Patra
Mar 7, 2019·Mini Reviews in Medicinal Chemistry·Luca ObertiLauritano Dorina
Nov 25, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A Al-HassinyA M Rich

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