Abstract
So far, no studies have been conducted to evaluate possible correlations between lipid/lipoprotein levels and the anti-phospholipid antibody (aPL) positivity in multiple sclerosis (MS). In this cross-sectional study, we aimed to investigate the relationships between serum lipid profile and aPL positivity rates in MS patients, and their possible differences among secondary-progressive MS (SPMS) patients, relapsing-remitting MS patients in remission (REM) and in relapse (REL). We included 16 SPMS, 58 REM and 26 REL. Their sera were tested for aPL (anti-cardiolipin, anti-β2glycoproteinI, anti-prothrombin, anti-annexinV), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and lipoprotein(a) levels. High TC levels were more frequent in SPMS patients than other groups (p=0.05). The REL had significantly higher rates of positivity for anti-β2glycoproteinI IgM (p<0.0001), anti-prothrombin IgG and IgM (both p=0.05) than the other groups. A significant positive correlation was found between age and both TC and LDL-C, disability and both TC and LDL-C, disease duration and LDL-C. TC levels were significantly higher (p=0.007) in anti-annexinV-IgG positive pat...Continue Reading
References
Aug 1, 1990·Neurology·S R LevineK M Welch
Nov 1, 1983·Neurology·J F Kurtzke
Sep 18, 1998·Archives of Neurology·O P Sharma
Oct 20, 1998·Annals of Neurology·D KarussisO Abramsky
Jul 13, 2002·Arthritis and Rheumatism·James R O'DellGerald Moore
Jul 24, 2003·Neuroscience Letters·C E TeunissenD Lütjohann
Jan 13, 2005·Rheumatology·S FerreiraG R V Hughes
May 10, 2005·Arthritis and Rheumatism·Barri J FesslerUNKNOWN LUMINA Study Group
Jul 20, 2005·Circulation·Caron P Misita, Stephan Moll
Oct 20, 2007·BMC Neurology·Carlos J BidotAlireza Minagar
Jul 16, 2008·Autoimmunity Reviews·Eiji MatsuuraMunther A Khamashta
Jul 23, 2009·Thrombosis Journal·Mohammad ShojaieSamira Dana
Dec 8, 2009·Blood·Jacob H RandDouglas J Taatjes
Apr 1, 2010·Lupus·J H RandD J Taatjes
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 30, 2011·Autoimmunity Reviews·L IaccarinoA Doria
Oct 6, 2011·Journal of Neuroinflammation·Bianca Weinstock-GuttmanMurali Ramanathan
Sep 14, 2012·Neurological Research·Yuval KarmonBianca Weinstock-Guttman
Sep 14, 2012·Neurological Research·Robert ZivadinovBianca Weinstock-Guttman
Sep 19, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ashwani K SingalKarl E Anderson
Oct 16, 2012·Disease Models & Mechanisms·Jean E Vance
Mar 15, 2013·The New England Journal of Medicine·Bill Giannakopoulos, Steven A Krilis
Apr 16, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A KardysM Ramanathan
Jun 14, 2013·PloS One·Ada FioriniMarzia Perluigi
Aug 21, 2013·Multiple Sclerosis : Clinical and Laboratory Research·C van de KraatsC E Teunissen
Mar 25, 2014·Lancet·Jeremy ChatawayRichard Nicholas
Mar 29, 2014·Current Medical Research and Opinion·Anil PareekKunal Kothari
May 16, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Prudence TetteyIngrid van der Mei
May 23, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Tatiana KoudriavtsevaPaola Cordiali-Fei
Nov 15, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Anquan LiuJohan Frostegård
Citations
Feb 10, 2016·Multiple Sclerosis and Related Disorders·Simon ZhornitskyManu Rangachari
Sep 3, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shreya MukhopadhyayMurali Ramanathan
Feb 24, 2017·Scientific Reports·Winde JorissenJerome J A Hendriks
Jan 11, 2018·International Journal of Molecular Sciences·Winde JorissenJerome J A Hendriks
May 9, 2018·Clinical Drug Investigation·Domenico Plantone, Tatiana Koudriavtseva
Dec 26, 2017·Frontiers in Immunology·Jo MailleuxJerome J A Hendriks
Oct 13, 2019·Reviews in the Neurosciences·Ahmed LotfyMohamed Salama
Nov 21, 2018·Acta Neuropathologica Communications·Elien GrajchenJeroen F J Bogie
Jan 30, 2019·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
Apr 4, 2019·Frontiers in Cellular Neuroscience·Chiara D'AngeloSilvia Sánchez-Ramón
May 16, 2019·Journal of Lipid Research·Kelly Fellows MaxwellMurali Ramanathan
Nov 20, 2018·Scientific Reports·A R GafsonP M Matthews
Nov 17, 2020·Frontiers in Immunology·Tatiana KoudriavtsevaMatilde Inglese
Apr 10, 2020·The Journal of Physical Chemistry. B·Myong In OhDonald F Weaver
Jul 1, 2018·Endocrine Regulations·Zofia RadikovaPeter Turcani