Anti-annexin antibodies, cholesterol levels and disability in multiple sclerosis

Neuroscience Letters
Chiara MandojTatiana Koudriavtseva

Abstract

So far, no studies have been conducted to evaluate possible correlations between lipid/lipoprotein levels and the anti-phospholipid antibody (aPL) positivity in multiple sclerosis (MS). In this cross-sectional study, we aimed to investigate the relationships between serum lipid profile and aPL positivity rates in MS patients, and their possible differences among secondary-progressive MS (SPMS) patients, relapsing-remitting MS patients in remission (REM) and in relapse (REL). We included 16 SPMS, 58 REM and 26 REL. Their sera were tested for aPL (anti-cardiolipin, anti-β2glycoproteinI, anti-prothrombin, anti-annexinV), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and lipoprotein(a) levels. High TC levels were more frequent in SPMS patients than other groups (p=0.05). The REL had significantly higher rates of positivity for anti-β2glycoproteinI IgM (p<0.0001), anti-prothrombin IgG and IgM (both p=0.05) than the other groups. A significant positive correlation was found between age and both TC and LDL-C, disability and both TC and LDL-C, disease duration and LDL-C. TC levels were significantly higher (p=0.007) in anti-annexinV-IgG positive pat...Continue Reading

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Citations

Feb 10, 2016·Multiple Sclerosis and Related Disorders·Simon ZhornitskyManu Rangachari
Sep 3, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Shreya MukhopadhyayMurali Ramanathan
Jan 11, 2018·International Journal of Molecular Sciences·Winde JorissenJerome J A Hendriks
Oct 13, 2019·Reviews in the Neurosciences·Ahmed LotfyMohamed Salama
Nov 21, 2018·Acta Neuropathologica Communications·Elien GrajchenJeroen F J Bogie
Jan 30, 2019·Frontiers in Neurology·Domenico PlantoneTatiana Koudriavtseva
May 16, 2019·Journal of Lipid Research·Kelly Fellows MaxwellMurali Ramanathan
Nov 20, 2018·Scientific Reports·A R GafsonP M Matthews
Nov 17, 2020·Frontiers in Immunology·Tatiana KoudriavtsevaMatilde Inglese
Apr 10, 2020·The Journal of Physical Chemistry. B·Myong In OhDonald F Weaver

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