Jan 1, 1976

Anti-arrhythmic action of nadolol, a beta-adrenergic receptor blocking agent

European Journal of Pharmacology
D B EvansR J Laffan

Abstract

The anti-arrhythmic action of 2,3-cis-1,2,3,4-tetrahydro-5-[(2-hydroxy-3-tert-butylamino)propoxy]2,3-naphthalenediol (nadolol) was evaluated and compared with that of propranolol in several experimental models of cardiac arrhythmias. Both nadolol and propranolol antagonized isoproterenol-induced tachycardia and ouabain-induced arrhythmias in cats, antagonized coronary artery ligation-induced ventricular fibrillation and suppressed ventricular ectopic activity during vagal stimulation in dogs. In contrast to propranolol, nadolol was considerably weaker in suppressing existing digoxin-induced arrhythmias, lacked local anesthetic activity and did not depress the heart in dogs. Because of these findings, it is concluded that the anti-arrhythmic activity of nadolol is apparently related to blockade of beta-adrenergic receptors.

Mentioned in this Paper

Ventricular Fibrillation
Vagal Stimulation
Digoxin
Anti-Arrhythmia Agents
Ouabain
Antiarrhythmic [EPC]
TERT gene
Entire Coronary Artery
2,3-naphthalenediol
Nerve Conduction Function

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