Anti-arrhythmic peptide N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly-OH reduces dispersion of action potential duration during ischemia/reperfusion in rabbit hearts

Journal of Cardiovascular Pharmacology
Anne Louise KjølbyeJørgen S Petersen

Abstract

During ischemia, cardiac gap junctions close and neighboring cells uncouple. This leads to slow conduction, increased dispersion of APD90 (duration from action potential beginning to 90% of repolarization), nonuniform anisotropy, and unidirectional conduction block, all of which favor the induction of reentry arrhythmias. It has been suggested that anti-arrhythmic peptides increase gap junction conductance during states of reduced coupling. The aim of this study was to test the effect of the anti-arrhythmic peptide N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly-OH (HP-5) (10(-10) ) on dispersion of epicardial APD90 during both normokalemic and hypokalemic ischemia/reperfusion in isolated perfused rabbit hearts. HP-5 did not affect average APD90, heart rate, left ventricular contractility (LVP dP/dtmax), or mean coronary flow. HP-5 significantly reduced the epicardial APD dispersion during hypokalemic ischemia (HP-5 treated: 24.1 +/- 3.4 ms, untreated: 33.9 +/- 3.1 ms, p < 0.05 versus untreated) and during normokalemic reperfusion but not during normokalemic ischemia or control conditions. In addition, among untreated hearts subjected to hypokalemic ischemia/reperfusion, seven of 10 developed ventricular fibrillation, wherea...Continue Reading

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Citations

Jan 30, 2009·Cardiovascular Research·Anja HagenStefan Dhein
Jun 19, 2009·Cardiovascular Research·Sevasti-Maria ChaldoupiHarold V M van Rijen
Mar 13, 2014·FEBS Letters·Christina L GrekGautam S Ghatnekar
Jul 25, 2009·Cell Communication & Adhesion·Xiao-Qing QuanCun-Tai Zhang
Jan 27, 2011·British Journal of Pharmacology·Elke De VuystLuc Leybaert
Jun 4, 2004·Journal of Cardiovascular Pharmacology·Ketil HauganJørgen Søberg Petersen
Jun 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Anne Louise KjølbyeJorgen Søberg Petersen
Oct 31, 2015·Anesthesia and Analgesia·Daisuke MaruyamaMichiaki Yamakage
Jan 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dezhi XingJames B Martins
Nov 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Anne Louise KjølbyeDavid S Rosenbaum

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