Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway disease

Immunopharmacology and Immunotoxicology
You-yi XiongChenggui Miao

Abstract

Crocin, a diterpenoid glucoside, has multitudinous activities such as anti-inflammation, anti-allergy, anti-oxidation and relaxing smooth muscles. In this study, the potential of crocin as an anti-asthma agent was investigated in a murine model. BALB/c mice were sensitized and challenged by ovalbumin (OVA) to induce allergic airway inflammation, with crocin administered one hour before every OVA challenge. Airway hyper-reactivity was evaluated by lung function analysis systems. Leukocyte counts in bronchoalveolar lavage fluid (BALF) were measured by a hemocytometer and Diff-Quick-stained smears. Lung tissues were stained with hematoxylin-eosin, Congo red and methylene blue for histopathological inspection. Inflammatory mediators in serum, BALF and lung were measured by ELISA or RT-PCR. Effects of crocin on MAPK signaling pathways were investigated by western blot analysis. Crocin significantly suppressed airway inflammation and hyper-reactivity, reduced levels of BALF interleukin (IL-4), IL-5, IL-13 and tryptase, lung eosinophil peroxidase and serum OVA-specific IgE, and inhibited the expression of lung eotaxin, p-ERK, p-JNK and p-p38 in the OVA-challenged mice. These results demonstrated that the suppression of crocin on airwa...Continue Reading

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Citations

Apr 22, 2016·Phytotherapy Research : PTR·Mohammad Hossein Boskabady, Tahereh Farkhondeh
Jul 5, 2017·The Journal of Pharmacy and Pharmacology·Reyhane Hoshyar, Homa Mollaei
Jan 24, 2019·Journal of Cellular Physiology·Mehran PashirzadSeyed Mahdi Hassanian
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Aug 24, 2019·Critical Reviews in Food Science and Nutrition·Kexin WangZhenxing Li
Jul 9, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahmoud HashemzaeiRamin Rezaee
Jun 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad Reza KhazdairMohammad Hossein Boskabady

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