PMID: 7539084Jan 1, 1995Paper

Anti-beta 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops

Journal of Molecular and Cellular Cardiology
G WallukatH F Pitschner

Abstract

In a preceding communication (Wallukat et al., 1992, Z Kardiol 81 [Suppl. 4]: 79-83), it was reported that synthetic peptides, corresponding in amino acid sequence to either the first or the second extracellular loop of the human beta 1-adrenoceptor, selectively suppressed the metoprolol- and bisoprolol-sensitive positive chronotropic action exerted in cultures of beating neonatal rat cardiomyocytes by the serum immunoglobulin fraction of patients with myocarditis and idiopathic dilated cardiomyopathy (DCM) and by affinity-purified autoantibodies from that fraction. These observations added to existing evidence that these antibodies were directed against the beta 1-adrenoceptor and might thus contribute to the harmful chronic cardiac adrenergic drive to which patients with DCM are believed to be exposed. Specifically, they pointed to the putative first and second extracellular loops of this receptor (these loops are each identical in man and the rat) as the sites of epitopes recognized by the chronotropically active, beta 1-agonistic autoantibodies. Now we report on the mapping of these epitopes with the help of two series of short synthetic overlap peptides, one series forming part of the first and the other of the second extr...Continue Reading

Citations

Oct 10, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angela Kallwellis-OparaStephan B Felix
Sep 8, 2010·Journal of Cardiovascular Translational Research·Emma J Birks, Robert S George
May 1, 1996·International Journal of Cardiology·Y MagnussonJ Hoebeke
May 1, 1996·International Journal of Cardiology·G WallukatG Baumann
Apr 27, 2005·Journal of Molecular and Cellular Cardiology·Luis E D GiménezEleonora Kurtenbach
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Apr 6, 2002·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Bernhard MaischSabine Pankuweit
Feb 11, 2005·The New England Journal of Medicine·Julie R Ingelfinger
Feb 11, 2005·The New England Journal of Medicine·Duska DragunGerd Wallukat
Jul 5, 2013·European Heart Journal·Alida L P CaforioUNKNOWN European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·G SchneiderR Kunze
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Oct 9, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hongliang LiXichun Yu
Apr 6, 2000·The American Journal of Cardiology·G WallukatR Hetzer
Jul 31, 2007·Journal of the American College of Cardiology·Viacheslav O NikolaevRoland Jahns
Jun 23, 2016·International Journal of Cardiology·Shivanjali Joshi-BarrGerd Wallukat
Mar 17, 2007·Journal of Molecular and Cellular Cardiology·Lisa BuvallMichael Fu
Jul 5, 2016·European Journal of Pharmacology·Annekathrin HaberlandGerd Wallukat
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Feb 7, 2017·Autoimmunity Reviews·Niels-Peter BeckerIngolf Schimke
Mar 15, 2018·PloS One·Gerd WallukatIngolf Schimke

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