Anti-beta 1-adrenoreceptor autoantibodies and myocardial sympathetic nerve activity in chronic heart failure

International Journal of Cardiology
Shin-ichi AsoUichi Ikeda

Abstract

The autoantibodies stimulate the beta1-adrenoreceptors on cardiac myocytes similar to norepinephrine, and are associated with reduced cardiac function. Iodine-123 metaiodobenzylguanidine ((123)I-MIBG) is metabolized similarly to norepinephrine. This study was undertaken to investigate the relationship between cardiac stimulation by anti-beta1-adrenoreceptor autoantibodies and myocardial sympathetic nervous activity in patients with chronic heart failure. We screened for the anti-beta1-adrenoreceptor autoantibodies in 52 patients with chronic heart failure by conducting an enzyme-linked immunosorbent assay, and underwent (123)I-MIBG scintigraphy in 27 of the patients. Anterior planar images of (123)I-MIBG were obtained 15 min and 3 h after the injection. We determined the heart to mediastinum radioactivity ratio (H/M), and calculated the rate of washout of (123)I-MIBG from the heart. Patients with New York Heart Association functional class III or IV had higher levels of anti-beta1-adrenoreceptor autoantibodies than those with class I or II (p<0.01). The autoantibody level was significantly correlated with delayed H/M (r=-0.65, p<0.001) and washout rate (r=0.65, p<0.001). Sixteen patients with a cardiac event showed higher level...Continue Reading

References

Jun 1, 1996·Circulation Research·M UngererG Richardt
May 1, 1996·Circulation·G EisenhoferM D Esler
Feb 19, 2002·Journal of the American College of Cardiology·Stephan B FelixKarl Stangl

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Citations

Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Udi Nussinovitch, Yehuda Shoenfeld
Jul 15, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Masatoshi MinamisawaUichi Ikeda

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