PMID: 8608682Nov 1, 1995Paper

Anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome

Clinical Rheumatology
V PengoA Ruffatti

Abstract

Autoimmune antiphospholipid antibodies are a hallmark of patients with antiphospholipid syndrome, and require a protein cofactor, beta 2-glycoprotein I, to bind anionic phospholipids. In these same patients, moreover, IgG directly binding beta 2-glycoprotein I are described. We found high plasma titres of both IgM and IgG anti beta 2-glycoprotein I antibodies in a patient with catastrophic antiphospholipid syndrome. After passing plasma through a Sephacryl S-300 column, an identical distribution pattern between anti beta 2- glycoprotein I and anticardiolipin antibodies was observed. Moreover, when IgG immunocomplexes were isolated from a high molecular fraction, IgM anti- beta 2-glycoprotein I and anticardiolipin antibodies were detected. Thus IgG, IgM ad IgG-IgM complexes of anti-beta 2-glycoprotein I antibodies are present at the same time in a patient with antiphospholipid syndrome.

References

Sep 1, 1992·The Journal of Clinical Investigation·R A RoubeyJ B Winfield
Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·I ZivM Sokolovsky
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H P McNeilS A Krilis
Jan 1, 1987·Annals of the Rheumatic Diseases·A E GharaviG R Hughes
Jun 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A Biasiolo, V Pengo

❮ Previous
Next ❯

Citations

Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·N Del PapaP L Meroni
Dec 11, 1999·International Journal of Clinical & Laboratory Research·J D KohlesV A DeBari
Aug 16, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Andre A Kaplan
Dec 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bor-Show TzangTsai-Ching Hsu
Oct 4, 2005·La Revue de médecine interne·E ChauvetC Vela
Nov 7, 2002·Critical Care Clinics·Gloria E Westney, E Nigel Harris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.