Anti-beta 2 glycoprotein I antibodies in centenarians

Experimental Gerontology
P L MeroniClaudio Franceschi


Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported. To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians. Seventy-seven centenarians, 70 adult controls, 65 unselected elderly subjects, and 38 old SENIEUR volunteers were investigated. Anti-cardiolipin, anti-human beta 2 glycoprotein I, and lupus anticoagulant were detected. Antigen specificity was assayed against plates coated with anionic, neutral and cationic phospholipids and beta 2 glycoprotein I-dependence was also evaluated. 54.3% of the centenarians were positive for IgG and 8.6% for IgM anti-beta 2 glycoprotein I antibodies, while only 20.7% centenarians were positive for anti-cardiolipin IgG and 2.59% for IgM; none resulted positive for lupus anticoagulant. Anti-cardiolipin positive sera cross-reacted with negatively charged phospholipids and displayed decreased binding to serum-free cardiolipin-coated plates that was restored by human beta 2 glycoprotein I or fetal calf serum. Centenarians display high reactivity against human beta 2 glycoprotein...Continue Reading


Apr 13, 1996·Lancet·Daniela MariClaudio Franceschi
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·L Casciola-RosenM Schlissel
Jun 19, 1998·Circulation·J C Piette, P Cacoub
Aug 29, 2000·Current Opinion in Hematology·R A Roubey
Sep 2, 2000·Journal of Autoimmunity·S S PierangeliE N Harris
Oct 18, 2001·Current Opinion in Hematology·B A Bouchard, P B Tracy
Oct 18, 2001·Current Opinion in Rheumatology·P L Meroni, P Riboldi
Jul 12, 2002·The New England Journal of Medicine·Phillip Periman


Apr 11, 2013·Immunologic Research·Francesca PregnolatoP L Meroni
Apr 30, 2008·Rejuvenation Research·Giuseppina Colonna-RomanoCalogero Caruso
Oct 25, 2008·Immunity & Ageing : I & a·Daniela MariDomenico Lio
Jul 1, 2014·PloS One·Christina DuftnerMichael Schirmer
Aug 16, 2011·Pathologie-biologie·A MankaïI Ghedira
Nov 26, 2009·Autoimmunity Reviews·Martina Biggioggero, P L Meroni
Jun 23, 2009·Trends in Immunology·Marc E WekslerClaudio Franceschi
Jul 22, 2015·Annals of the New York Academy of Sciences·Nichol E Holodick, Thomas L Rothstein
Sep 18, 2007·Experimental Gerontology·Daniela MariRita Provenzano
Nov 24, 2007·Journal of Thrombosis and Haemostasis : JTH·P L MeroniA Tincani
Jul 25, 2006·Critical Reviews in Oncology/hematology·Massimo Franchini
Oct 3, 2015·Immunologic Research·Monowar AzizPing Wang
Nov 19, 2008·Journal of Neuroinflammation·Brian GiuntaJun Tan
Aug 19, 2007·Experimental Gerontology·Miriam CapriClaudio Franceschi
Oct 30, 2016·Trends in Endocrinology and Metabolism : TEM·Claudio FranceschiStefano Salvioli
Jun 1, 2018·Annual Review of Nutrition·Claudio FranceschiAurelia Santoro
Jan 13, 2018·Nature Reviews. Disease Primers·Karen SchreiberBeverley J Hunt
Mar 19, 2020·Current Opinion in Rheumatology·Jacqueline A MadisonJason S Knight
Oct 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Aline R SchindlerPeter B Luppa

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