Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis

MedChemComm
Karlie E Cox, Christian Melander

Abstract

Bacteria employ a number of mechanisms to resist the effects of antibiotics, including the formation of biofilms. We explored the anti-biofilm capabilities of a library of compounds based upon a 2-aminoquinazoline (2-AQ) scaffold against Mycobacterium smegmatis. This study resulted in the identification of 2-AQ derivatives with biofilm inhibition activity against M. smegmatis.

References

Feb 13, 2001·Trends in Microbiology·T F Mah, G A O'Toole
Mar 21, 2001·Antimicrobial Agents and Chemotherapy·K Lewis
Apr 5, 2002·Clinical Microbiology Reviews·Rodney M Donlan, J William Costerton
Feb 4, 2012·Organic & Biomolecular Chemistry·Erick A LindseyChristian Melander
Aug 20, 2014·Journal of Medicinal Chemistry·Christopher M BrackettChristian Melander
Nov 26, 2015·The New England Journal of Medicine·C Robert HorsburghChristoph Lange

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Citations

Jul 2, 2020·Natural Product Reports·Roberta J MelanderChristian Melander
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael A TrebinoFitnat H Yildiz

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Methods Mentioned

BETA
acylation

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