PMID: 22583405May 16, 2012Paper

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds

Anti-cancer Agents in Medicinal Chemistry
Jinhui ZhangJunxuan Lü

Abstract

Korean Angelica gigas Nakai (AGN) is a major medicinal herb used in Asian countries such as Korea and China. Traditionally, its dried root has been used to treat anemia, pain, infection and articular rheumatism in Korea, most often through boiling in water to prepare the dosage forms. The pyranocoumarin compound decursin and its isomer decursinol angelate (DA) are the major chemical components in the alcoholic extracts of the root of AGN. The in vitro anti-tumor activities of decursin and/or DA against prostate cancer, lung cancer, breast cancer, colon cancer, bladder cancer, sarcoma, myeloma and leukemia have been increasingly reported in the past decade whereas the in vivo efficacy in mouse models was established only for a few organ sites. Preliminary pharmacokinetic studies by us and others in rodent models indicated that decursinol (DOH), which has much less in vitro direct anticancer activities by itself, is the major and rapid in vivo hydrolysis metabolite of both decursin and DA. Besides decursin, DA and DOH, other chemical components in AGN such as polysaccharides and polyacetylenes have been reported to exert anti-cancer and anti-inflammation activities as well. We systematically reviewed the published literature on t...Continue Reading

Citations

Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Donna M Raditic, Joseph W Bartges
Feb 11, 2016·Complementary Therapies in Medicine·Hyun-Mok JuKi Han Kwon
Mar 8, 2016·Asian-Australasian Journal of Animal Sciences·Wenchie Marie L LumberaSeong Gu Hwang
Sep 24, 2015·The American Journal of Chinese Medicine·Jinhui ZhangJunxuan Lü
Jan 23, 2017·International Journal of Biological Macromolecules·Hyun Woo LeeHoon Kim
Jul 5, 2017·The Journal of Pharmacy and Pharmacology·Hanbing LiLinghuan Li
Apr 30, 2017·Scientia pharmaceutica·Kandhasamy Sowndhararajan, Songmun Kim
Dec 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chinreddy Subramanyam ReddySung Cheol Koo
May 14, 2018·Microbial Cell Factories·Roberta CallariNora Weber
Sep 26, 2017·Molecular Medicine Reports·Kang Min LeeSeong-Gyu Ko
Aug 30, 2018·BioMed Research International·Yong-Joon JeonYe Sun Han
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Bagher MajnooniAnupam Bishayee
Nov 14, 2019·International Journal of Molecular Sciences·Rui ChenYan Liang
Mar 12, 2020·Anti-cancer Agents in Medicinal Chemistry·Mükerrem Betül YererKatrin Sak
Sep 24, 2021·Chemistry & Biodiversity·Majid MohammadhosseiniSatyajit D Sarker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.