PMID: 25735374Mar 5, 2015Paper

Anti-cancer properties of a sesquiterpene lactone-bearing fraction from Artemisia khorassanica

Asian Pacific Journal of Cancer Prevention : APJCP
Shahrzad Taghizadeh RabeMahmoud Mahmoudi

Abstract

Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects. Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting. The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c. The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma.

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Citations

Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Zahra Tayarani-NajaranSeyed Ahmad Emami
Apr 25, 2015·Journal of Experimental & Clinical Cancer Research : CR·Caroline van HaaftenTom van Wezel

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