Anti-cancer study and whey protein complexation of new lanthanum(III) complex with the aim of achieving bioactive anticancer metal-based drugs

Journal of Biomolecular Structure & Dynamics
Somaye ShahrakiSomaye Dahmardeh

Abstract

In this study, a new lanthanum (III)-amino acid complex utilizing cysteine has been synthesized and characterized. The anticancer activities of the prepared La(III) complex against MCF-7 cell lines were studied. Results of MTT assay showed that at all three incubation times, the cytotoxic effect of prepared La(III) complex on MCF-7 breast cancer cell lines displays a time- and dose-dependent inhibitory effects. The interactions of the La(III) complex with two whey proteins (bovine serum albumin, BSA, and Bovine β-lactoglobulin, βLG) have been explored by using spectroscopic and molecular dicking methods. The obtained results indicated that La(III) complex strongly quenched the fluorescence of two carrier proteins in static quenching mode and also, BSA hah stronger binding affinity toward studied complex than βLG whit binding constant values of KBSA-La Complex ∼ 0.11 × 104 M-1 and KβLG-La Complex ∼ 0.63 × 103 M-1 at 300 K. The thermodynamic parameters revealed the contribution of hydrogen bond and Vander Waals interactions in both systems. The distances of the La(III) complex whit whey proteins were calculated using Förster energy transfer theory and proved existence of the energy transfer between two proteins and prepared La(II...Continue Reading

References

Jan 1, 1978·International Journal of Psychiatry in Medicine·F M Lewis, J R Bloom
Jul 1, 1981·Analytical Biochemistry·M R Eftink, C A Ghiron
Jan 1, 1994·Advances in Protein Chemistry·D C Carter, J X Ho
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·I D KuntzP A Kollman
Oct 25, 2001·Analytical Biochemistry·J R Lakowicz
Jun 13, 2002·Chemical Reviews·Koen Binnemans, Christiane Görller-Walrand
Jan 28, 2005·Reviews of Physiology, Biochemistry and Pharmacology·M A JakupecB K Keppler
May 25, 2005·Bioorganic & Medicinal Chemistry·Jianniao TianXingguo Chen
Jul 12, 2005·Journal of Photochemistry and Photobiology. B, Biology·Yan-Jun HuSong-Sheng Qu
Dec 31, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sean EkinsTatiana Nikolskaya
Jan 18, 2006·Journal of Pharmaceutical and Biomedical Analysis·P B KandagalO B Ijare
May 27, 2006·Chemical Society Reviews·Simon P Fricker
Sep 5, 2006·ChemMedChem·Ulf Norinder, Christel A S Bergström
Nov 1, 2007·Nature Reviews. Drug Discovery·Paul D Leeson, Brian Springthorpe
Nov 26, 2008·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Farzaneh RasoulzadehMohammad-Reza Rashidi
Jan 29, 2009·Biomacromolecules·Yan-Jun HuXiao-He Xiao
Sep 23, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Yuichi ShimazakiOsamu Yamauchi
Feb 16, 2010·Chemical Reviews·Jean-Claude G Bünzli
Apr 24, 2010·The Journal of Physical Chemistry. B·Li Liang, Muriel Subirade
May 17, 2011·International Journal of Biological Macromolecules·J EssemineH A Tajmir-Riahi
Jul 19, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ziyad A TahaAbeer A Al-Ghzawi
May 9, 2012·Journal of Photochemistry and Photobiology. B, Biology·Yan-Jun HuLi-Ping Zhang
May 26, 2012·Journal of Agricultural and Food Chemistry·Shevin R FerozSaad Tayyab
Jan 24, 2013·The Journal of Hand Surgery, European Volume·R J R Chennagiri, T R Lindau
Feb 6, 2013·Journal of Chemical Information and Modeling·David Ryan KoesCarlos J Camacho
Aug 27, 2013·The Protein Journal·Mohammed J FarooqiLorenzo Brancaleon
Oct 29, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Behafarid GhalandariMassoud Amanlou
Jan 15, 2014·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Krishanu Ray, Joseph R Lakowicz
Feb 1, 2014·Nature Reviews. Drug Discovery·Andrew L HopkinsCharles H Reynolds
Jan 7, 2015·Journal of Chemical Information and Modeling·Thomas SanderChristian Rufener
Dec 1, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·NeelimaDinesh Kumar
Dec 4, 2015·Toxins·Miklós PoórSándor Kunsági-Máté
Jan 19, 2016·Food Chemistry·Elena GuerciaFederico Berti
Mar 1, 2016·Bioorganic & Medicinal Chemistry·Banafsheh RastegariMasoud Nabavizadeh
Mar 26, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Mostafa Heidari MajdAzam Sargazi
Oct 22, 2016·Advanced Pharmaceutical Bulletin·Hassan Mansouri-TorshiziMostafa Heidari Majd
Jan 4, 2017·International Journal of Biological Macromolecules·P Chanphai, H A Tajmir-Riahi
Feb 6, 2017·Journal of Biomolecular Structure & Dynamics·Roohollah GhobadiAli Akbar Saboury
Mar 10, 2017·Journal of Biomolecular Structure & Dynamics·Md Maroof AlamImrana Naseem

❮ Previous
Next ❯

Citations

Feb 27, 2019·Expert Opinion on Drug Discovery·Edgar López-LópezJosé L Medina-Franco
Jun 2, 2020·Journal of Biomolecular Structure & Dynamics·Bhupesh S BhattTushar N Patel
Apr 5, 2020·International Journal of Molecular Sciences·Agnieszka RodzikBogusław Buszewski
May 21, 2019·Journal of Biomolecular Structure & Dynamics·Virendra R MishraNagaiyan Sekar
Jun 4, 2020·Environmental Science and Pollution Research International·Yichen QiuDenghang Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence spectroscopy
fluorescence
FRET
competition binding

Software Mentioned

Smina
ORSIS Data Warrior
AutoDock Vina
GaussView
Molegro Molecular Viewer
BIOVIA Discovery Studio

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.