Anti-cancer therapy with TNFα and IFNγ: A comprehensive review

Cell Proliferation
Jing ShenChi H Cho

Abstract

Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally found to be produced by inflammatory cells and play important roles in the immune system and surveillance of tumour growth. By activating distinct signalling pathways of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and JAK/STAT, TNFα and IFNγ were reported to effectively trigger cell death and perform powerful anti-cancer effects. In this review, we will discuss the new advancements of TNFα and IFNγ in anti-cancer therapy.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D LienardF J Lejeune
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·F BoueH Sancho-Garnier
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T YoshidaY Shimada
Dec 15, 1990·International Journal of Cancer. Journal International Du Cancer·S SuzukiY Hashimoto
Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W AulitzkyC Huber
Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Vadhan-RajS E Krown
Jan 1, 1986·Investigational New Drugs·H B MussR L Capizzi
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S ErnstoffJ M Kirkwood
Feb 1, 1988·The Journal of Urology·M B GarnickS A Rudnick
Apr 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R D'AcquistoJ L Lewis
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·K KimuraH Majima
Aug 1, 1988·The Journal of Experimental Medicine·P NawrothD Stern
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·P J CreavenA Proefrock
Mar 1, 1986·The Journal of Experimental Medicine·P P Nawroth, D M Stern
Jan 1, 1985·Cancer Immunology, Immunotherapy : CII·K A FoonR B Herberman
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M WiesenfeldR Pazdur
Nov 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R JettJ B Gerstner
Sep 1, 1994·The Journal of Urology·J A EllerhorstC J Logothetis
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W L FurmanC B Pratt
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Pujade-LauraineM Brandely
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M EggermontF J Lejeune
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H R AlexanderS A Rosenberg
Mar 29, 2000·British Journal of Cancer·G H WindbichlerC Marth
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Mar 20, 2002·Cytokine & Growth Factor Reviews·Hiroaki IkedaRobert D Schreiber
Sep 24, 2002·Journal of Cell Science·Roumen Pankov, Kenneth M Yamada
Aug 23, 2003·Blood·Laura BorsiLuciano Zardi
Mar 23, 2004·Annals of the New York Academy of Sciences·Annie Abadie, Juana Wietzerbin
Apr 20, 2004·Current Opinion in Structural Biology·Gongyi Zhang
Nov 18, 2004·American Journal of Obstetrics and Gynecology·Christian MarthGünter Daxenbichler
Sep 13, 2005·Biochemical and Biophysical Research Communications·Hun Sik KimMyung-Shik Lee

❮ Previous
Next ❯

Citations

Aug 24, 2019·Frontiers in Immunology·Antonio MarchiniJean Rommelaere
Mar 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Parisa LotfinejadBehzad Baradaran
May 21, 2021·Frontiers in Immunology·Amrita BasuKrithika Kodumudi
Jun 11, 2021·The Kaohsiung Journal of Medical Sciences·Dmitry Aminin, Yun-Ming Wang
Jun 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cong LiYihui Deng
Aug 27, 2021·ERJ Open Research·Maysa AlhawmdehMojgan Najafzadeh
Sep 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yohei YoshihamaRonald A DePinho
Oct 7, 2021·Journal of Cell Communication and Signaling·Zihong WuMasoud Najafi
Sep 12, 2020·Anti-cancer Agents in Medicinal Chemistry·Khandan IlkhaniMohammad-Reza Alivand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.