PMID: 12751686May 20, 2003Paper

Anti-Candida antibodies in serum and saliva of patients with denture stomatitis

Folia medica
Todor V Kantardjiev, Elka V Popova

Abstract

Quantitative measurement of IgA and IgG antibodies in the serum and saliva of patients with denture stomatitis (stomatitis subprothetica) was the object of this study. The indirect immunofluorescence technique (IFA) utilizing CIP 628 (serotype A) Candida albicans blastospores was employed. Anti-human goat and rabbit fluorescein isothiocyanate labeled serum was used. Serial serum dilutions from 1:20 to 1:1280 and saliva serial dilutions from 1:1 to 1:8 were prepared. Specimens were read using an ML-2 fluorescence microscope. Alternative analysis, analysis of variance and graphical analysis was used for statistical analysis of data. Anti-Candida antibodies (mainly IgG class) were detectable at dilutions of 1:40, 1:80 and 1:160 in the serum of patients with denture stomatitis compared with healthy controls. The saliva samples of these patients showed higher titers of anti-Candida antibodies compared with controls (1:8 for IgG and 1:4 for IgA). IgG anti-bodies were prevalent in the saliva of our patients and they were of diagnostic value. The IgA titers did not remain constant and could be a determinant of the disease course. Each patient showed an individual serologic profile. For this reason individualized interpretation of saliv...Continue Reading

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