Anti-carbamylated proteins antibody repertoire in rheumatoid arthritis: evidence of a new autoantibody linked to interstitial lung disease

Annals of the Rheumatic Diseases
Raul Castellanos-MoreiraRaimon Sanmarti

Abstract

To analyse the association between anti-carbamylated protein antibodies (Anti-CarP) and interstitial lung disease (ILD) in rheumatoid arthritis (RA) patients. Cross-sectional study including RA patients fulfilling the 2010 ACR/EULAR criteria. The main population comprised two groups: (1) RA patients diagnosed with RA-ILD (RA-ILD group); (2) RA patients without ILD (non-ILD RA group). Non-ILD RA patients in whom ILD was suspected underwent a diagnostic work-up and, if ILD was diagnosed, were switched to the RA-ILD group. ILD was diagnosed by high-resolution computed tomography and confirmed by a multidisciplinary committee. An independent replication sample was also obtained. Three Anti-CarP IgG autoantibodies against fetal calf serum (Anti-FCS), fibrinogen (Anti-Fib) and chimeric fibrine/filagrine homocitrullinated peptide (Anti-CFFHP) and one Anti-CarP IgA against FCS (Anti-FCS-IgA) were determined by home-made ELISA. Associations between Anti-CarP and ILD were analysed using multivariable logistic regression adjusted by smoking, sex, age, RA disease duration, rheumatoid factor and anticitrullinated protein antibodies. We enrolled 179 patients: 37 (21%) were finally diagnosed with RA-ILD. Anti-CarP specificities were more freq...Continue Reading

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Citations

Jul 24, 2020·Current Opinion in Pulmonary Medicine·Pierre-Antoine JugePhilippe Dieudé
Feb 26, 2021·Therapeutic Advances in Musculoskeletal Disease·Bogdan KolarzMaria Majdan
Feb 25, 2021·Current Opinion in Rheumatology·Gregory C McDermottJeffrey A Sparks
May 13, 2021·Scientific Reports·Cristina RegueiroAntonio Gonzalez
Jul 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Hiroshi FurukawaShigeto Tohma
Sep 9, 2021·Clinical Reviews in Allergy & Immunology·Maria V SokolovaUlrike Steffen

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