Anti-cataract activity of Pterocarpus marsupium bark and Trigonella foenum-graecum seeds extract in alloxan diabetic rats

Journal of Ethnopharmacology
V VatsJ K Grover

Abstract

Long-term complications are frequently encountered in diabetes mellitus and are difficult to treat. This study was undertaken to assess the effect of three antidiabetic plants on the development of cataract in rats. An aqueous extract of Pterocarpus marsupium Linn bark (PM, Hindi name: Vijaysar) (1 g kg(-1) day(-1)), Ocimum sanctum Linn leaves (OS, Hindi name, Tulsi) (200 mg kg(-1) day(-1)) and alcoholic extract of Trigonella foenum-graecum Linn seeds (FG, Hindi name, Methi) (2 g kg(-1) day(-1)) were given to alloxan (120 mg kg(-1)) diabetic rats until the development of cataract. Serum glucose and body weight were monitored at regular intervals while cataract was examined through naked eye as well as slit lamp at 75, 100 and 115 days after alloxan administration. Administration of all the three plant extracts exerted a favorable effect on body weight and blood glucose, the effects were best with PM followed by FG and OS. On the course of cataract development, PM followed by FG exerted anti-cataract effect evident from decreased opacity index while OS failed to produce any anti-cataract effect in spite of significant antihyperglycemic activity.

References

Dec 1, 1992·Diabetes Care·R KleinS E Moss
Feb 1, 1991·Archives of Ophthalmology·S K West
May 1, 1990·International Ophthalmology·B Thylefors
Jan 1, 1971·American Journal of Ophthalmology·L Von Sallmann, P Grimes
Aug 6, 1999·Current Eye Research·S Swamy-MruthintiE C Abraham
Dec 22, 1999·Journal of Agricultural and Food Chemistry·A PollackZ Madar
May 22, 2002·Journal of Ethnopharmacology·J K GroverV Vats
Nov 30, 2002·Phytotherapy Research : PTR·S S RathiN R Biswas

❮ Previous
Next ❯

Citations

Oct 6, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nihat DilsizAndreas Reichenbach
Oct 17, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Manal Abdul-Hamid, Nadia Moustafa
Apr 23, 2009·Indian Journal of Ophthalmology·S K GuptaRohit Saxena
Mar 8, 2014·Biological Trace Element Research·Lei SunQing Han
Feb 27, 2013·Free Radical Research·R Thiagarajan, R Manikandan
Aug 19, 2015·Journal of Ethnopharmacology·Arezou RezaeiMitra Khademi
May 9, 2006·Journal of Ethnopharmacology·Pulok K MukherjeePeter J Houghton
Sep 5, 2013·Colloids and Surfaces. B, Biointerfaces·Pavan SunkireddySubhash C Yadav
Oct 5, 2011·Asian Pacific Journal of Tropical Medicine·Rajesh KumarSiva Hemalatha
May 14, 2014·European Journal of Nutrition·Assaâd SilaZouheir Sahnoun
Sep 17, 2009·Human & Experimental Toxicology·A Ismail KhanK Balasubramanian
Feb 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorena AlmagroMaria Angeles Pedreño
Jul 3, 2019·Frontiers in Pharmacology·Devesh TewariGianina Crişan
Jan 23, 2020·Pharmaceuticals·Segewkal H HeruyeCatherine A Opere
Jul 7, 2020·Journal, Genetic Engineering & Biotechnology·Anupama Ammulu ManneSudhakar Podha
Dec 6, 2005·Molecular and Cellular Biochemistry·Mohamed Z GadNibal D El-Tanbouly
Dec 31, 2020·Drug Research·Sahar IdrisMd Khushtar
Jul 6, 2020·Journal of Pharmacological and Toxicological Methods·Lei ZhongShiqi Ling
Jun 12, 2021·Journal of Ethnopharmacology·Dаyаr АrbаinMuhammad Taher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.