Anti-CD20 monoclonal antibody treatment in 6 patients with therapy-refractory chronic graft-versus-host disease.

Blood
Marijke R Canninga-van DijkLeo Verdonck

Abstract

Chronic graft-versus-host disease (cGVHD) is an important determinant of long-term morbidity and mortality in allogeneic stem cell transplantation patients. Because cGVHD has clinical, histologic, and laboratory findings of autoimmune diseases and anti-B-cell therapy has shown efficacy in autoimmune diseases, we hypothesized that monoclonal anti-CD20 antibody therapy might improve patients with cGVHD. We treated 5 men and 1 woman with therapy-refractory extensive cGVHD with anti-CD20 monoclonal antibody. Intravenous infusion was given at a weekly dose of 375 mg/m(2) for 4 weeks. In case of incomplete clinical response, additional courses of 4 weeks were given. Five patients responded to treatment with marked clinical, biochemical, and histologic improvement. One patient failed to respond. Anti-CD20 monoclonal antibody seems to be effective in cGVHD. A controlled trial is mandatory to confirm these results. The outcome of this study suggests a participating role of B cells in the pathogenesis of cGVHD.

References

May 25, 1999·Bone Marrow Transplantation·F J ChildR Russell-Jones
Aug 14, 1999·Immunology·J C EdwardsV M Abrahams
Sep 21, 2000·British Journal of Haematology·S ChiodiA Bacigalupo
Jul 27, 2001·British Journal of Haematology·N AhrensA Salama
Jan 21, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel AndersonDaniel Weisdorf
Mar 26, 2003·Histopathology·M R Canninga-van DijkJ G van den Tweel

❮ Previous
Next ❯

Citations

Dec 3, 2005·Pharmaceutical Research·Pleunie P M RoodMassimo Trucco
Jun 23, 2009·International Journal of Hematology·Takanori TeshimaMine Harada
May 7, 2011·International Journal of Hematology·Mohamed A Kharfan-Dabaja, Corey S Cutler
Feb 19, 2008·Bone Marrow Transplantation·M MohtyD Blaise
Mar 12, 2008·Bone Marrow Transplantation·S J OhS Park
May 19, 2009·Rheumatology·Dimitrios DaoussisAndrew P Andonopoulos
Feb 8, 2006·Current Opinion in Oncology·Corey Cutler, Joseph H Antin
Aug 12, 2005·Current Opinion in Hematology·Amy L Dunn
Sep 25, 2008·Transplantation·Malte von BoninUwe Platzbecker
Nov 30, 2011·TheScientificWorldJournal·Jacopo OlivieriAttilio Olivieri
Mar 22, 2006·Acta Haematologica·Amy L Dunn, Thomas C Abshire
Mar 23, 2006·Blood·Corey CutlerEdwin Alyea
Sep 15, 2009·Blood·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Jun 23, 2006·Drugs·José A Pérez-SimónJesús San Miguel
Nov 3, 2010·Haematologica·Caron A Jacobson, Jerome Ritz
Aug 21, 2013·Blood Reviews·Irit AviviTamar Katz
Jun 6, 2007·Bone Marrow Transplantation·F ZajaUNKNOWN GITMO (Gruppo Italiano Trapianto Midollo Osseo)
Apr 25, 2007·Leukemia & Lymphoma·Angelo Michele CarellaEnrica Lerma
Oct 23, 2008·Expert Review of Hematology·John Koreth, Joseph H Antin
Apr 28, 2010·Expert Opinion on Biological Therapy·Sally Arai, David B Miklos
Jun 19, 2012·The Medical Clinics of North America·Daan DierickxAndré Delannoy
Mar 17, 2012·Journal of the American Academy of Dermatology·Sharon R HymesEdward W Cowen
Jun 1, 2010·Dermatologic Clinics·David R Carr, Michael P Heffernan
Dec 17, 2009·Seminars in Arthritis and Rheumatism·Dimitrios DaoussisAndrew P Andonopoulos
Sep 1, 2009·Autoimmunity Reviews·Thomas DörnerUNKNOWN International Roundtable on B cells as Therapeutic Target for Intervention
Aug 18, 2009·Cancer Treatment Reviews·Voravit RatanatharathornJoseph P Uberti
Nov 22, 2008·Journal of the American Academy of Dermatology·Asha R PatelEdward W Cowen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Voravit RatanatharathornJoseph P Uberti
Bone Marrow Transplantation
Francesco ZajaGITMO (Gruppo Italiano Trapianto Midollo Osseo)
© 2022 Meta ULC. All rights reserved