Anti-CD20 therapies and pregnancy in neuroimmunologic disorders: A cohort study from Germany.

Neurology. Neuroimmunology and Neuroinflammation
Tania KümpfelKerstin Hellwig


To report pregnancy outcomes and disease activity (DA) in women with MS, neuromyelitis optica spectrum disorders (NMOSDs), and other neuroimmunologic diseases (ONID) after treatment with rituximab (RTX)/ocrelizumab (OCR) 12 months before or during pregnancy. Data were collected in the German MS and pregnancy registry and centers from the Neuromyelitis Optica Study Group. Sixty-eight known outcomes of 88 pregnancies from 81 women (64 MS, 10 NMOSD, and 7 ONID) were included and stratified in 3 exposure groups: >6M-group = RTX/OCR >6 but ≤12 months before the last menstrual period (LMP) (n = 8); <6M group = RTX/OCR <6 months before the LMP (n = 47); preg group = RTX/OCR after the LMP (n = 13). Pregnancy outcomes were similar between groups, but significantly more preterm births (9.8% vs 45%) occurred after exposure during pregnancy. Overall, 2 major congenital abnormalities (3.3%), both in the preg group, were observed. Three women had severe infections during pregnancy. All women with MS (35) and 12/13 women with NMOSD, RTX/OCR exposure before the LMP and known pregnancy outcomes after gestational week 22 were relapse free during pregnancy. Five of 29 (17.2%) women with relapsing-remitting MS (RRMS) and 1 of 12 (8.3%) with NMOSD ...Continue Reading


Nov 26, 2010·Blood·Eliza F ChakravartyPamela Farmer
Apr 13, 2011·Neurology·Kerstin Hellwig, Ralf Gold
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Jul 10, 2013·Journal of Neurology·Yára Dadalti FragosoFabio Siquineli
May 21, 2014·Annals of the New York Academy of Sciences·Monika Ostensen
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Sep 19, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Ingrid MeinlTania Kümpfel
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