Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Samir P BhagwatFrancis Gigliotti

Abstract

The T cell-mediated immune response elicited by Pneumocystis plays a key role in pulmonary damage and dysfunction during Pneumocystis carinii pneumonia (PcP). Mice depleted of CD4(+) and CD8(+) T cells prior to infection are markedly protected from PcP-related respiratory deficit and death, despite progressive lung infection. However, the therapeutic effectiveness of Ab-mediated disruption of T cell function in mice already displaying clinical symptoms of disease has not been determined. Therefore, a murine model of PcP-related immune reconstitution inflammatory syndrome was used to assess whether Ab to the pan-T cell molecule CD3 is effective for reducing the severity of PcP when administered after the onset of disease. Mice that received anti-CD3 Ab exhibited a rapid and dramatic halt in the PcP-associated pulmonary function decline within 1 week after treatment, and a striking enhancement of survival rate compared with mice receiving the control Ab. Physiologic improvement in anti-CD3 treated mice was associated with a significant reduction in the number of CD4(+) and CD8(+) T cells recovered in lung lavage fluid. This effectiveness of anti-CD3 was noted whether the mice also received antibiotic therapy with trimethoprim-sul...Continue Reading

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Citations

Jul 10, 2013·Infection and Immunity·David M RicksJay K Kolls
Sep 10, 2011·Interdisciplinary Perspectives on Infectious Diseases·Jing WangFrancis Gigliotti
Dec 24, 2014·Ocular Immunology and Inflammation·Marjan FaridLbachir BenMohamed
Nov 18, 2015·Immunological Investigations·Kausik Datta, Mawieh Hamad
Apr 29, 2015·Infection and Immunity·Theodore J KottomAndrew H Limper
Nov 26, 2014·Seminars in Immunopathology·Taylor Eddens, Jay K Kolls
Aug 28, 2020·The Journal of International Medical Research·Ying WenYan Yin
Aug 27, 2021·Journal of Fungi·Eléna CharpentierXavier Iriart

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