Anti-CD3 epsilon F(ab')2 prevents graft-versus-host disease by selectively depleting donor T cells activated by recipient alloantigens

The Journal of Immunology : Official Journal of the American Association of Immunologists
X Z YuC Anasetti

Abstract

Transplantation tolerance is facilitated by activation-induced apoptosis of peripheral T cells triggered by specific AG: Abs specific for the nonpolymorphic CD3 component of the TCR complex bind to APCs through Fc-FcR interactions, mimic MHC-peptide, and activate polyclonal T cells. In contrast, F(ab')(2) of anti-CD3epsilon Abs do not activate naive T cells but induce apoptosis of Ag-activated, cycling T cells. Here, we report that treatment with anti-CD3epsilon F(ab')(2) can selectively induce apoptosis of donor T cells that recognize a recipient alloantigen, thereby preventing graft-vs-host disease initiated by a TCR-transgenic T cell population. The selective elimination of Ag-activated T cells by non-FcR-binding anti-CD3epsilon Abs could serve as an ideal strategy to prevent graft-vs-host disease and allograft rejection or to treat autoimmune disorders.

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Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·X Z YuC Anasetti

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Citations

Jul 2, 2005·Expert Opinion on Emerging Drugs·Robert Gniadecki, Martin J Calverley
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xue-Zhong YuClaudio Anasetti
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xue-Zhong YuClaudio Anasetti
Oct 1, 2010·Current Opinion in Organ Transplantation·Sylvaine You, Lucienne Chatenoud
Jun 11, 2005·European Journal of Immunology·Chiu-Chen HuangRong-Hwa Lin
Nov 8, 2011·Immunotherapy·Ben SprangersChantal Mathieu
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xue-Zhong YuChen Dong
Jan 5, 2002·Journal of the American Academy of Dermatology·James G Krueger

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