May 7, 2010

Anti-CD30 Antibodies for Hodgkin lymphoma

Current Hematologic Malignancy Reports
Kelley V Foyil, Nancy L Bartlett


Treatment of refractory or relapsed classical Hodgkin lymphoma (HL) remains challenging, but targeted immunotherapy has recently emerged as a potential treatment option for these patients. Although first-generation monoclonal anti-CD30 antibodies proved disappointing, current efforts to modify anti-CD30 antibodies to improve binding of effector cells and enhance activity appears more promising, as does the development of novel antibody-drug conjugates (ADCs). ADCs offer the potential to deliver potent therapies with minimal toxicity. One highly active ADC, brentuximab vedotin (SGN-35), combines an anti-CD30 monoclonal antibody and the antitubulin agent monomethyl auristatin E. Initial phase 1 studies of brentuximab vedotin showed a 52% overall response rate in relapsed HL, with minimal toxicity. This article highlights the development of anti-CD30 antibodies and ADCs for relapsed or refractory classical HL.

  • References37
  • Citations27


Mentioned in this Paper

Monoclonal Antibodies
Antineoplastic Agents
SGN-30 monoclonal antibody
Antigens, CD30
Brentuximab vedotin
TNFRSF8 gene
Clinical Trials

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