PMID: 7529544Dec 1, 1994Paper

Anti-CD36 antibodies in patients with lupus anticoagulant and thrombotic complications

British Journal of Haematology
G RockN N Tandon

Abstract

Six patients with lupus anticoagulant with thrombotic complications, but not exhibiting systemic lupus erythematosus, demonstrated the presence in their plasma of antibodies directed against platelet antigens which were not detectable in two patients presenting with lupus anticoagulant but without thrombotic complications. Protein blotting of separated normal platelet proteins against patient plasma gave up to 18 bands of varying intensity indicative of multiple antiplatelet antibodies; one of these antibodies recognized a component with a mobility identical with CD36 (GPIV; m.w. 88,000) in 4/6 cases. Antibodies to CD36 and one or two other components were identified in 5/6 cases by immunoprecipitation from 125I-labelled control platelets and 6/6 by dot blots against purified CD36. These results suggest that antiplatelet antibodies and, specifically, anti CD36 antibodies, occur frequently in the plasma of patients presenting with lupus anticoagulant and thrombotic complications.

References

Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M HuangJ S Brugge
Dec 1, 1994·British Journal of Haematology·N N TandonG A Jamieson

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Citations

Sep 1, 1996·Arthritis and Rheumatism·R A Roubey
Jan 9, 2010·International Journal of Hematology·Han-Mou Tsai
Jul 11, 2000·British Journal of Haematology·G A Rock
Jan 1, 1996·Annual Review of Medicine·S S Shapiro
Jan 22, 2009·Journal of Neuroinflammation·Lawrence L HorstmanAlireza Minagar
Mar 26, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Yimin Ge, M Tarek Elghetany
Jan 31, 2009·Kidney International. Supplement·Gail A Rock, William F Clark
Oct 4, 2005·British Journal of Haematology·Gail RockPeter McLaine
Apr 2, 2005·British Journal of Haematology·Gail RockUNKNOWN Canadian Association of Apheresis Nurses
May 12, 1998·Vascular Medicine·A K RaoR Kaplan
Jun 6, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gail RockBernd Stegmayr
Dec 6, 2005·Immunobiology·Pierre Youinou

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