Anti-CD43 and anti-galectin-1 autoantibodies in patients with systemic lupus erythematosus

Scandinavian Journal of Rheumatology
J L MontielY Rosenstein

Abstract

Systemic lupus erythematosus (SLE) is characterized by the production of multiple autoantibodies and also by T-cell dysfunction. CD43 is expressed by most immune cells, is involved in lymphocyte adhesion and activation, and interacts with galectin-1 (Gal-1). The aim of this work was to evaluate the plasma levels of autoantibodies against CD43 and Gal-1 as well as the levels of soluble Gal-1 in SLE Mexican mestizo patients, with the aim of establishing a correlation between these parameters and the clinical profile. Serum levels of immunoglobulin (Ig)G autoantibodies against CD43 and Gal-1 and levels of soluble Gal-1 were measured by enzyme-linked immunosorbent assay (ELISA) in 55 patients with SLE and 71 healthy controls. We found significantly enhanced titres of anti-CD43 and anti-Gal-1 antibodies in sera from SLE patients compared to controls. In addition, the serum levels of Gal-1 were significantly higher in SLE patients than in healthy individuals. However, we could detect no correlation of these parameters with disease activity [using the Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI)], age, or a variety of different clinical or laboratory features. Similarly, no significant correlation with immu...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B ArdmanD E Staunton
Nov 21, 1991·Nature·Y RosensteinS J Burakoff
Jun 1, 1984·The Journal of Experimental Medicine·E Remold-O'DonnellF S Rosen
Aug 1, 1996·Glycoconjugate Journal·C Hafer-MackoL G Baum
Jun 27, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·D LutomskiM Caron
Apr 7, 1998·Immunity·B M StocktonU H von Andrian
Dec 8, 1998·The Journal of Experimental Medicine·R C WoodmanP Kubes
Aug 3, 1999·The Journal of Experimental Medicine·G A RabinovichY Chernajovsky
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K E PaceL G Baum
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J T NguyenL G Baum
Feb 6, 2004·Glycoconjugate Journal·Ken Scott, Cristina Weinberg
Oct 27, 2004·Seminars in Arthritis and Rheumatism·Yaniv ShererYehuda Shoenfeld
Nov 4, 2004·Biochemical and Biophysical Research Communications·Roxana del RioGustavo Pedraza-Alva
Jun 15, 2005·Critical Reviews in Immunology·Gyorgy NagyAndras Perl
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanori MatsumotoTakako Hirata
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brianna N StillmanLinda G Baum
Mar 24, 2006·Revista médica de Chile·Evelyn PardoAndrea Soza
Mar 28, 2006·Investigative Ophthalmology & Visual Science·Marta D RomeroGabriel A Rabinovich
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marta A ToscanoGabriel A Rabinovich
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nora A FierroYvonne Rosenstein
Aug 10, 2006·Current Opinion in Rheumatology·Aimee E Pugh-Bernard, John C Cambier
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph D HernandezLinda G Baum
Oct 21, 2006·Journal of Autoimmunity·Amy E WandstratNancy J Olsen
Nov 18, 2006·Blood·Marina I GarínRobert I Lechler
Feb 20, 2007·Lancet·David P D'CruzGraham R V Hughes
Aug 24, 2007·Advances in Experimental Medicine and Biology·Joost J OppenheimDe Yang
Nov 27, 2007·BMC Immunology·Oscar Ramírez-PliegoM Angélica Santana
Feb 29, 2008·The New England Journal of Medicine·Anisur Rahman, David A Isenberg
Jul 16, 2008·Autoimmunity Reviews·Biji T Kurien, R Hal Scofield

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Citations

Jul 4, 2012·Glycobiology·Rosanna E RamhorstGabriel A Rabinovich
Mar 7, 2014·Clinical Rheumatology·Dinglei SuLingyun Sun
Jul 24, 2012·FEBS Letters·Hortensia de la FuenteFrancisco Sánchez-Madrid
Mar 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dong TangKuirong Jiang
Oct 22, 2016·Autoimmunity Reviews·Francesca SacconAndrea Doria
May 11, 2021·Autoimmunity Reviews·Wang-Dong XuAn-Fang Huang

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