Anti-CD45RB monoclonal antibody-mediated transplantation tolerance

Current Molecular Medicine
P P W LukeRobert Zhong

Abstract

Currently, lifelong immunosuppression is required for organ transplant recipients. The majority of transplant recipients will eventually develop chronic rejection with resultant graft loss, despite treatment with powerful immunosuppressive agents. These agents are also associated with numerous toxicities including reduced immunity against infection and malignancy. Therefore, the central goal in transplant science is to devise tolerance strategies in an attempt to establish a state of prolonged non-reactivity against the allograft, accompanied with preservation of an intact immune system. Although predictable tolerance induction has been elusive, we found that short course of the novel immunomodulatory agent, anti-CD45RB monoclonal antibody, leads to indefinite acceptance of renal allografts in mice, and has been shown to markedly prolong allograft survival in primates. We review the current state of development of this antibody, and the progress made in defining its mechanism of action.

Citations

Mar 19, 2008·Transplant Immunology·Huanfa YiYong Zhao
Dec 16, 2004·Pediatric Transplantation·Nancy R Krieger, Sukru Emre
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G ChenR Zhong
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P P W LukeR Zhong
Jul 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D GolshayanR I Lechler
Jul 7, 2015·PloS One·Ilaria Grazia ZizzariChiara Napoletano
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jeffrey B MatthewsJeffrey A Bluestone
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei-Ping MinRobert Zhong

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