Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort

Arthritis Research & Therapy
Janneke J de WinterDominique Baeten

Abstract

Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA. Anti-CD74 IgG and IgA antibodies were first measured in an exploratory cohort of patients with radiographic axSpA (138 patients with ankylosing spondyloarthritis (AS)) and 57 healthy controls and then were measured in patients with early axSpA (n = 274) and with non-SpA chronic back pain (CBP) (n = 319), participating in the spondyloarthritis caught early (SPACE) prospective cohort study of patients under 45 years old with early back pain (for ≥ 3 months, but ≤ 2 years). In the exploratory cohort, anti-CD74 IgG antibodies were present in 79.7% of patients with AS vs. 43.9% of healthy controls (p < 0.001). Anti-CD74 IgA antibodies were present in 28.5% of patients with AS vs. 5.3% of healthy controls (p < 0.001). In the SPACE cohort, anti-CD74 IgG antibody levels were present in 46.4% of the patients with axSpA vs. 47.9% of the patients with CBP (p = 0.71). Anti-CD74 IgA antibodies were present in 54.7% of the patients with axSpA and 37.0% of the patients with CBP (p < 0.001). This resulted in a positive predictive value of 58.8% (com...Continue Reading

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Citations

Feb 21, 2018·European Journal of Clinical Investigation·Anoek de KoningFloris A van Gaalen
Jan 9, 2019·Arthritis & Rheumatology·Nigil Haroon
Jun 17, 2019·Current Rheumatology Reports·Victoria Navarro-Compán
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Feb 7, 2019·Frontiers in Immunology·Yuan LiuGuixiu Shi
Jul 6, 2019·Journal of Immunology Research·Devis BenfaremoArmando Gabrielli
Jan 25, 2021·Autoimmunity Reviews·Solveig Skovlund GroenSigne Holm Nielsen
Dec 20, 2020·Seminars in Arthritis and Rheumatism·Shanshan XuFaming Pan
Jun 12, 2021·Nature Reviews. Rheumatology·Daniele MauroFrancesco Ciccia

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Methods Mentioned

BETA
imaging techniques
enzyme-linked immunosorbent assays
ELISAs
ESR

Software Mentioned

SPACE

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