Anti-cholesterol antibody levels in hereditary angioedema.

Journal of Cellular and Molecular Medicine
Lilian VargaHenriette Farkas

Abstract

Hereditary angioedema (HAE) is a rare disorder caused by the deficiency of the C1-inhibitor gene (C1INH) and characterized by recurrent bouts of angioedema. Autoimmune disorders frequently occur in HAE. Previously we found, that danazol has an adverse effect on serum lipid profile: reduced high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL) cholesterol levels are associated with long-term prophylactic use, whereas total cholesterol levels are unchanged. Our aim was to study the anti-cholesterol antibody (ACHA) production in HAE patients and compare it with those of healthy blood donors, and to investigate the possible associations between ACHA levels and serum lipid profile alterations caused by danazol. Anti-cholesterol IgG levels were measured by ELISA and their correlation with serum concentrations of total cholesterol, HDL, LDL, triglycerides was determined in HAE patients receiving/not receiving danazol. Serum ACHA levels were significantly higher in HAE patients, compared to healthy blood donors (P<0.0001). Longterm danazol prophylaxis had no effect on serum ACHA levels in HAE patients. However, we found a significant, negative correlation between ACHA levels and serum total cholesterol (r=-0.4033, P...Continue Reading

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Citations

Jun 4, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henriette FarkasPéter Gergely
Jul 2, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ibolya CzallerHenriette Farkas
Jan 4, 2013·The World Allergy Organization Journal·Timothy CraigMarcus Maurer
Jul 26, 2011·Clinical Biochemistry·Raman K MarwahaKuntal Bhadra

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