Anti-citrullinated peptide antibodies are the strongest predictor of clinically relevant radiographic progression in rheumatoid arthritis patients achieving remission or low disease activity: A post hoc analysis of a nationwide cohort in Japan

PloS One
Tomohiro KogaJapanese RA Patients with RRP Study Group

Abstract

To determine prognostic factors of clinically relevant radiographic progression (CRRP) in patients with rheumatoid arthritis (RA) achieving remission or low disease activity (LDA) in clinical practice. Using data from a nationwide, multicenter, prospective study in Japan, we evaluated 198 biological disease-modifying antirheumatic drug (bDMARD)-naïve RA patients who were in remission or had LDA at study entry after being treated with conventional synthetic DMARDs (csDMARDs). CRRP was defined as the yearly progression of modified total Sharp score (mTSS) >3.0 U. We performed a multiple logistic regression analysis to explore the factors to predict CRRP at 1 year. We used receiver operating characteristic (ROC) curve to estimate the performance of relevant variables for predicting CRRP. The mean Disease Activity Score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) was 2.32 ± 0.58 at study entry. During the 1-year observation, remission or LDA persisted in 72% of the patients. CRRP was observed in 7.6% of the patients. The multiple logistic regression analysis revealed that the independent variables to predict the development of CRRP were: anti-citrullinated peptide antibodies (ACPA) positivity at baseline (OR = 15.2, 95%...Continue Reading

References

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Citations

Aug 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L Heinlen, M B Humphrey
Dec 18, 2019·Immunological Reviews·Mikhail VolkovDiane van der Woude
Mar 15, 2018·Current Opinion in Rheumatology·Lazaros I Sakkas, Dimitrios P Bogdanos
Oct 9, 2020·The Tohoku Journal of Experimental Medicine·Ryu WatanabeMakio Gamoh
Jan 26, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tomohiro KogaGeorge C Tsokos

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