Anti-citrullinated peptide antibodies in lupus patients with or without deforming arthropathy

Lupus
G N Damián-AbregoA R Cabral

Abstract

The objective was to study the association of antibodies against cyclic citrullinated peptides (anti-CCP) in patients with lupus articular damage. We studied 34 systemic lupus erythematosus patients (30 women) with (n = 14) or without (n = 20) deforming arthropathy. Anti-DNA and arthritis were mandatory inclusion criteria for both groups. As controls, 34 patients with rheumatoid arthritis and nine patients with rheumatoid arthritis and systemic lupus erythematosus (rhupus) were included. Anti-CCP and rheumatoid factor were determined by ELISA and nephelometry respectively. All patients had recent x-ray films of the hands that were evaluated according to Sharp's method. Systemic lupus erythematosus patients had a mean 6.50 +/- 0.86 (SD, range 5-8) American College of Rheumatology (ACR) criteria, rheumatoid arthritis patients met 5.38 +/- 0.60 (range 4-6) ACR criteria for rheumatoid arthritis and rhupus patients had 5.78 +/- 0.44 (range 5-6) criteria for rheumatoid arthritis and 5.11 +/- 0.78 (range 4-6) for systemic lupus erythematosus. Systemic lupus erythematosus patients, with or without deforming arthropathy, had normal serum anti-CCP concentrations. In contrast, rheumatoid arthritis and rhupus patients had 30- and 23-fold h...Continue Reading

References

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May 29, 2007·Arthritis and Rheumatism·Nicola BizzaroYehuda Shoenfeld

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Citations

Jun 18, 2009·Rheumatology International·Abdullah UyanikRamazan Cetinkaya
May 26, 2011·Rheumatology International·Usha SinghSuman Singh
Dec 20, 2011·Rheumatology·Elisabeth M A Ball, Aubrey L Bell
Feb 16, 2013·Clinical Rheumatology·Thelma L SkareVanessa Picceli
Jan 1, 2014·Modern Rheumatology·Ana Letícia Pirozzi BuosiRita Nely Vilar Furtado
Feb 19, 2013·Reumatología clinica·Lilia Andrade-OrtegaVictor Manuel Rosales-Don Pablo
Dec 24, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Panomkorn LhakumWorawit Louthrenoo
Dec 24, 2015·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Shiwen YuanXiuyan Yang
Jul 14, 2009·Best Practice & Research. Clinical Rheumatology·Jennifer M Grossman
Mar 3, 2010·Immunological Reviews·Ann Duskin, Robert A Eisenberg
Jun 30, 2012·Autoimmunity Reviews·Luca IaccarinoAndrea Doria
Jun 6, 2012·Yonsei Medical Journal·Sung Bin ChoDongsik Bang
Mar 13, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Verena GalvãoMittermayer B Santiago

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