Anti-clastogenic activity of two structurally related pterocarpans purified from Bituminaria bituminosa in cultured human lymphocytes

Mutation Research
Tiziana MaurichGino Turchi

Abstract

Plant-derived isoflavones are currently receiving much attention because of their phyto-estrogenic, antioxidant, anti-mutagenic, and anti-tumor activities. In this study we have evaluated the clastogenic and anti-clastogenic activities in human lymphocytes of two structurally related pterocarpans, iso-flavonoid derivatives, termed erybraedin C and bitucarpin A, recently purified from Bituminaria bituminosa and chemically characterized. Mitomycin C (MMC) and the radio-mimetic bleomycin (BL) were used as reference clastogens. The end point studied was micronucleus formation. The results obtained in this study indicate that erybraedin C and bitucarpin A, when assayed alone, do not affect either the mitotic index or the cell-proliferation index of human lymphocytes. Interestingly, both compounds appear to be non-clastogenic in the range of concentrations used. In contrast, both substances seem to affect significantly the clastogenic effects induced by BL and MMC. A 1-h pre-exposition of the cell culture to erybraedin C was necessary to display its anti-clastogenic potential against BL, whereas bitucarpin A was inactive in this respect, with a structure-activity relationship. In contrast, the clastogenic activity of MMC was signific...Continue Reading

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Citations

May 27, 2005·Chemical Communications : Chem Comm·Leticia Jiménez-GonzálezIgnacio Rodríguez-García
Jun 22, 2014·Biochimie·Gardenia C G MilitãoGláucia M Machado-Santelli
Aug 28, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yasir Hasan SiddiqueMohammad Afzal
Mar 30, 2017·Natural Product Research·R V Bandeira ReidelL Pistelli
Jan 2, 2008·Phytotherapy Research : PTR·B PintoL Pistelli
Sep 6, 2006·Chemistry : a European Journal·Leticia Jiménez-GonzálezIgnacio Rodríguez-García
May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Yan WangShao-Qing Cai
Sep 5, 2014·Organic & Biomolecular Chemistry·Shital K ChattopadhyayRatnava Maitra
Oct 31, 2016·Food Science and Biotechnology·Cengiz SarikurkcuBektas Tepe

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