Anti-coccidial properties and mechanisms of an edible herb, Bidens pilosa, and its active compounds for coccidiosis

Scientific Reports
Wen-Chin YangCicero Lee-Tian Chang

Abstract

Avian coccidiosis is an economically important disease in the poultry industry. In view of the disadvantages of anti-coccidial drugs in chickens, edible plants and their compounds are re-emerging as an alternative strategy to combat this disease. A previous publication reported that the edible plant B. pilosa showed promise for use against coccidiosis. Here, we first investigated into the anti-coccidial effects of B. pilosa. We found that B. pilosa at 100 ppm or more significantly suppressed E. tenella as evidenced by reduction in mortality rate, oocyst excretion and gut pathological severity in chickens and its minimum prophylactic duration was 3 days. Next, we explored the mode of action of anti-coccidial mechanism of B. pilosa. The E. tenella oocysts were not directly killed by B. pilosa; however, administration of the plant suppressed oocyst sporulation, sporozoite invasion, and schizonts in the life cycle of E. tenella. Besides, B. pilosa boosted T cell-mediated immunity. Finally, we characterized the related anti-coccidial phytochemicals and their mode of action. One of three potent polyynes present in B. pilsoa, Compound 1 (cytopiloyne), acted against coccidiosis in chickens in a similar manner to B. pilosa. These data i...Continue Reading

References

Jul 1, 1996·Clinical Microbiology Reviews·H S Lillehoj, J M Trout
Aug 1, 1997·Poultry Science·P C AllenH D Danforth
Mar 27, 2001·Veterinary Parasitology·H J Youn, J W Noh
Nov 13, 2004·BMJ : British Medical Journal·Merlin L Willcox, Gerard Bodeker
Feb 3, 2006·Expert Review of Vaccines·Rami A Dalloul, Hyun S Lillehoj
Jan 19, 2007·Toxicology and Applied Pharmacology·Shu-Lin ChangWen-Chin Yang
Apr 6, 2007·Journal of Ethnopharmacology·Shu-Lin ChangWen-Chin Yang
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cicero Lee-Tian ChangWen-Chin Yang
Jun 1, 1997·Avian Pathology : Journal of the W.V.P.A·H D Chapman
Jun 16, 2009·Parasitology·V McDonald, M W Shirley
Aug 18, 2009·Phytochemistry·Shih-Chang ChienWen-Chin Yang
Apr 27, 2010·Parasitology International·Emilio del CachoCaridad Sánchez-Acedo
Jul 16, 2010·Parasite Immunology·P A SharmanM Katrib
Aug 25, 2010·Pharmaceutical Biology·Marley GarcíaRamón Scull
Jul 6, 2011·Veterinary Parasitology·Adnane RemmalFouzia Chami
Dec 16, 2011·Veterinary Parasitology·Masood AkhtarMuhammad Irfan Anwar
Oct 2, 2012·Veterinary Parasitology·S A BurtJ C M Vernooij
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Arlene P BartolomeWen-Chin Yang
Dec 3, 2014·Research in Veterinary Science·W C YangC L T Chang
Apr 22, 2016·Scientific Reports·Cicero Lee-Tian ChangWen-Chin Yang
Oct 21, 2016·Data in Brief·Chih-Yao ChungCicero Lee-Tian Chang

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Citations

Mar 21, 2020·Parasite : Journal De La Société Française De Parasitologie·Zhenchao ZhangXiangrui Li
Jun 3, 2021·Parasite : Journal De La Société Française De Parasitologie·Thabile MadlalaMatthew Adekunle Adeleke
Jul 25, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Ali DaneshmandShu-Biao Wu

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BETA
nuclear magnetic resonance

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SAS

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