Anti-cyclo-oxygenase agents and asthma

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
A Szczeklik

Abstract

Aspirin inhibits cyclo-oxygenase by an irreversible time-dependent process of inactivation; this mechanism appears to be responsible for precipitation of asthmatic attacks in about 5%-10% of adult asthmatic patients. Besides aspirin, all other cyclo-oxygenase inhibitors induce bronchoconstriction in sensitive patients, while nonsteroidal anti-inflammatory drugs without anti-cyclo-oxygenase activity can be taken by the same patients with impunity. While aspirin-sensitive patients should avoid the potential for adverse reactions, there are rare reports of bronchodilation following ingestion of aspirin and aspirinlike drugs.

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Citations

Apr 3, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Catherine L HaggertyGrant W Waterer
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C J Falliers

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